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| Product Name: | BO-264 | | Synonyms: | BO-264;4-Pyrimidinamine, N-[3-(4-methoxyphenyl)-5-isoxazolyl]-2-(4-morpholinyl)-;3-(4-Methoxyphenyl)-N-(2-morpholinopyrimidin-4-yl)isoxazol-5-amine;inhibit,cytotoxicity,antitumor,Fibroblast growth factor receptor,BO-264,Apoptosis,Inhibitor,TACC3,spindle,abnormalities,FGFR,ERK1/2,BO 264,DNA,phosphorylation,FGFR3-TACC3,mitotic,damage,anti-proliferative,BO264 | | CAS: | 2408648-20-2 | | MF: | C18H19N5O3 | | MW: | 353.38 | | EINECS: | | | Product Categories: | | | Mol File: | 2408648-20-2.mol |  |
| | BO-264 Chemical Properties |
| Boiling point | 627.9±65.0 °C(Predicted) | | density | 1.306±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | Soluble in DMSO (>25 mg/ml) | | form | solid | | pka | 6.69±0.10(Predicted) | | color | Off-white | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| | BO-264 Usage And Synthesis |
| Description | BO-264 (2408648-20-2) is a potent (IC50 = 188 nM) inhibitor of transforming acidic coiled-coil 3 (TACC3), an important protein involved in microtubule stability and centrosome integrity.1 TACC3 is frequently upregulated in a broad range of cancers. BO-264 displayed significant anticancer activity in greater than 90% of cell lines in the NCI-60 human cancer cell line panel. Active in vivo in mice injected with JIMT-1 and EMT6 breast cancer cells as well as mouse colon cancer xenografts HCT-116 and CT-26. | | References | References: |
| | BO-264 Preparation Products And Raw materials |
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