顺式-8，11，14-二十烷三烯酸甲酯
| 中文名称 | 顺式-8，11，14-二十烷三烯酸甲酯 |
|---|---|
| 中文同义词 | 顺式-8，11，14-二十烷三烯酸甲酯;顺式-8,11,14-二十碳三烯酸;8,11,14-二十碳三烯酸;二十碳三烯酸(顺-8,11,14);全顺-8,11,14-二十碳三烯酸;顺式 - 8,11,14-二十碳三烯的酸;顺-8,11,14-二十碳三烯酸甲酯 (C20:3N6) 溶液;顺-8,11,14-二十碳三烯酸甲酯 (C20:3N6) |
| 英文名称 | CIS-8,11,14-EICOSATRIENOIC ACID |
| 英文同义词 | DIHOMO-GAMMA-LINOLENIC ACID;DIHOMO-GAMMA-LINOLENIC ACID-CONTAINING TRIGLYCERIDE;EICOSA-8Z,11Z,14Z-TRIENOIC ACID;CIS,CIS,CIS-8,11,14-EICOSATRIENOIC ACID;CIS-8,11,14-EICOSATRIENOIC ACID;DELTA 8 CIS 11 CIS 14 CIS EICOSATRIENOIC ACID;DGLA;HOMO-GAMMA-LINOLENIC ACID |
| CAS号 | 1783-84-2 |
| 分子式 | C20H34O2 |
| 分子量 | 306.48 |
| EINECS号 | 217-233-0 |
| 相关类别 | 脂肪酸甲酯;脂肪酸甲酯溶液;合成;脂肪酸;提取;中药对照品;Aliphatics;Fatty Acid Derivatives & Lipids;Glycerols |
| Mol文件 | 1783-84-2.mol |
| 结构式 |  |
顺式-8，11，14-二十烷三烯酸甲酯 性质
| 沸点 | 200°C(lit.) |
|---|---|
| 密度 | 0.917±0.06 g/cm3(Predicted) |
| 折射率 | n |
| 闪点 | 144 °F |
| 储存条件 | -20°C |
| 溶解度 | 氯仿：50 mg/mL，澄清，无色 |
| 酸度系数(pKa) | 4.77±0.10(Predicted) |
| 形态 | 液体 |
| 颜色 | 无色至淡黄色 |
| BRN | 1796533 |
| 稳定性 | 感光 |
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Human Endogenous Metabolite
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Dihomo-γ-linolenic acid attenuates pro-inflammatory gene expression in human and mouse macrophages.
Dihomo-γ-linolenic acid (50 μM; 24 hours) attenuates IFN-γ induced phosphorylation of STAT1 on serine 727.
Dihomo-γ-linolenic acid attenuates IL-1β and TNF-α induced MCP-1 and ICAM-1 expression in human macrophages.
Dihomo-γ-linolenic acid attenuates chemokine-driven monocytic migration and macrophage foam cell formation.
Dihomo-γ-linolenic acid attenuates the expression of SR-A and CD36 in human macrophages.
Dihomo-γ-linolenic acid modulates mitochondrial respiration.
Dihomo-γ-linolenic acid modulates the properties of endothelial cells and VSMC.
Western Blot Analysis
| Cell Line: | THP-1 macrophages |
| Concentration: | 50 μM (pre-treated) |
| Incubation Time: | 24 hours |
| Result: | Attenuated IFN-γ induced phosphorylation of STAT1 on serine 727. |
Dihomo-γ-linolenic acid (8 mg/mouse; i.g; twice a week; for 35 days) inhibits growth of xenograft tumors in mice bearing human pancreatic cancer cells (BxPC-3) transfected with delta-5-desaturase shRNA.
| Animal Model: | Female nude mice (48 four-week old) |
| Dosage: | 8 mg/mouse |
| Administration: | Oral gavage, twice a week, for 35 days |
| Result: | Suppressed metastasis potential in D5D-KD tumors. |
| 提供商 | 语言 |
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英文
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