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1,1,1,2,3,3,3-Heptafluoropropane Basic information
Product Name:1,1,1,2,3,3,3-Heptafluoropropane
Product Categories:Refrigerant;refrigerants
Mol File:431-89-0.mol
1,1,1,2,3,3,3-Heptafluoropropane Structure
1,1,1,2,3,3,3-Heptafluoropropane Chemical Properties
Melting point -126.8°C
Boiling point -16.4°C
density 1,409 g/cm3
refractive index 1.2747 (estimate)
solubility Soluble 1 in 1725 parts of water at 20°C.
Stability:Stable. Incompatible with strong oxidizing agents, alkali metals
LogP1.610 (est)
CAS DataBase Reference431-89-0(CAS DataBase Reference)
NIST Chemistry Reference1,1,1,2,3,3,3-Heptafluoropropane(431-89-0)
EPA Substance Registry SystemHFC-227ea (431-89-0)
Safety Information
Hazard Codes Xi
Safety Statements 23-38
Hazard Note Irritant
HazardClass 2.2
HS Code 2903460010
Hazardous Substances Data431-89-0(Hazardous Substances Data)
Toxicitymouse,LC,inhalation,> 7200gm/m3/4H (7200000mg/m3),BEHAVIORAL: MUSCLE WEAKNESSBEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)LUNGS, THORAX, OR RESPIRATION: DYSPNEA,Toksikologicheskii Vestnik. Vol. (3), Pg. 37, 1996.
MSDS Information
1,1,1,2,3,3,3-Heptafluoropropane English
1,1,1,2,3,3,3-Heptafluoropropane Usage And Synthesis
Chemical PropertiesHeptafluoropropane is a liquefied gas and exists as a liquid at room temperature when contained under its own vapor pressure, or as a gas when exposed to room temperature and atmospheric pressure. The liquid is practically odorless and colorless. The gas in high concentration has a faint etherlike odor. Heptafluoropropane is noncorrosive, nonirritating, and nonflammable.
UsesHFC 227ea is being developed as a CFC replacement in refrigerants, high temperature heat pumps, air-conditioning systems; as a fire suppressant; and for pharmaceutical aerosols and metered-dose inhalers.
Flammability and ExplosibilityNon flammable
Pharmaceutical ApplicationsHeptafluoropropane is classified as a hydrofluorocarbon (HFC) aerosol propellant since the molecule consists only of carbon, fluorine, and hydrogen atoms. It does not contain any chlorine and consequently does not affect the ozone layer, nor does it have an effect upon global warming. It is therefore considered as an alternative propellant to CFCs for metered-dose inhalers (MDIs). While some of its physical and chemical properties are known, little has been published in regard to its use as a replacement for CFCs in MDIs.
The vapor pressure of heptafluoropropane is somewhat lower than that of tetrafluoroethane and dichlorodifluoromethane but considerably higher than the vapor pressure used to formulate most MDIs.
When heptafluoropropane is used for pharmaceutical aerosols and MDIs, the pharmaceutical grade must be specified. Industrial grades may not be suitable due to their impurity profile. Similarly to tetrafluoroethane, heptafluoropropane is not a good solvent for medicinal agents or for the commonly used surfactants and dispersing agents used in the formulation of MDIs.
There are several MDIs formulated with this propellant worldwide that contain a steroid as the active ingredient.
SafetyHeptafluoropropane is used as a fire extinguisher and is applicable as a non-CFC propellant in various metered-dose inhalers. Heptafluoropropane is regarded as nontoxic and nonirritating when used as directed. No acute or chronic hazard is present when it is used normally. Inhaling high concentrations of heptafluoropropane vapors can be harmful and is similar to inhaling vapors of other propellants. Deliberate inhalation of vapors of heptafluoropropane can be dangerous and may cause death. The same labeling required of CFC aerosols would be required for those containing heptafluoropropane as a propellant (except for the EPA requirement).
storageHeptafluoropropane is a nonreactive and stable material. The liquefied gas is stable when used as a propellant and should be stored in a metal cylinder in a cool, dry place.
Tag:1,1,1,2,3,3,3-Heptafluoropropane(431-89-0) Related Product Information
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