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| | 1-(4-CHLORO-BENZYL)-1 H-INDOLE-3-CARBALDEHYDE Basic information |
| | 1-(4-CHLORO-BENZYL)-1 H-INDOLE-3-CARBALDEHYDE Chemical Properties |
| Melting point | 115.0 to 119.0 °C | | Boiling point | 465.5±30.0 °C(Predicted) | | density | 1.21±0.1 g/cm3(Predicted) | | storage temp. | Inert atmosphere,2-8°C | | solubility | DMSO: ≥20mg/mL | | form | powder | | color | off-white to light tan | | Sensitive | Light Sensitive |
| Hazard Codes | Xi | | WGK Germany | 3 | | HS Code | 2933.99.9000 | | HazardClass | IRRITANT |
| | 1-(4-CHLORO-BENZYL)-1 H-INDOLE-3-CARBALDEHYDE Usage And Synthesis |
| Uses | Oncrasin 1 is a proapoptotic compound. | | Definition | ChEBI: Oncrasin-1 is a member of the class of indoles that is 1H-indole substituted by 4-chlorobenzyl and formyl groups at positions 1 and 3, respectively. It is an anti-cancer agent that is active against lung cancer cells with K-Ras mutations. It has a role as an apoptosis inducer and an antineoplastic agent. It is a member of indoles, a member of monochlorobenzenes and an arenecarbaldehyde. | | Biological Activity | Proapoptotic agent that induces abnormal nuclear aggregation of PKC ι and suppresses RNA transcription. Exhibits antiproliferative effects against various human tumor cell lines with K-Ras mutations (IC 50 ≤ 3 μ M) with minimal effects on normal epithelial cells and inhibits human xenograft growth by 75% in vivo . | | storage | +4°C |
| | 1-(4-CHLORO-BENZYL)-1 H-INDOLE-3-CARBALDEHYDE Preparation Products And Raw materials |
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