- GBR 12783
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- $2500.00 / 100mg
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2025-10-27
- CAS:67469-57-2
- Min. Order:
- Purity:
- Supply Ability: 10g
- GBR 12783
-
- $2500.00 / 100mg
-
2025-07-25
- CAS:67469-57-2
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | 1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYL-2-PROPENYL)-PIPERAZINE DIHYDROCHLORIDE Basic information |
| | 1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYL-2-PROPENYL)-PIPERAZINE DIHYDROCHLORIDE Chemical Properties |
| Melting point | >200°C (dec.) | | Boiling point | 551℃ | | density | 1.085 | | Fp | 148℃ | | storage temp. | Desiccate at -20°C | | solubility | Methanol (Slightly), Water (Slightly, Heated) | | form | Solid | | color | White to Off-White |
| | 1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYL-2-PROPENYL)-PIPERAZINE DIHYDROCHLORIDE Usage And Synthesis |
| Chemical Properties | White to off-white powder | | Uses | GBR 12783 is a very potent and selective inhibitor of dopamine uptake. | | Definition | ChEBI: 1-[2-(diphenylmethyl)oxyethyl]-4-(3-phenylprop-2-enyl)piperazine is a diarylmethane. | | Biological Activity | A very potent and selective inhibitor of dopamine uptake (IC 50 for inhibition of [ 3 H]-dopamine uptake in rat striatal synaptosomes is 1.8 nM). | | in vivo | GBR 12783 (10 mg/kg; intraperitoneal injection; for 100 minutes; male Sprague-Dawley rats) treatment reinforces specifically dopamine transmission only at synapses instantaneously active, increases hippocampal ACh release and improves memory performance in a passive avoidance task[1]. | Animal Model: | Male Sprague-Dawley rats (180-200 g)[1] | | Dosage: | 10 mg/kg | | Administration: |
Intraperitoneal injection; for 100 minutes | | Result: | For a moderate electric shock intensity (0.4 mA), improveed retention performance, increased hippocampal acetylcholine release in vivo.
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| | 1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYL-2-PROPENYL)-PIPERAZINE DIHYDROCHLORIDE Preparation Products And Raw materials |
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