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Glycolonitrile

Glycolonitrile Basic information
Product Name:Glycolonitrile
Synonyms:cyanomethanol;HYDROXYACETONITRILE;GLYCOLONITRILE;GLYCOLIC ACID NITRILE;FORMALDEHYDE CYANHYDRIN;2-Hydroxymethylnitrile;Glykolonitril;HOCH2CN
CAS:107-16-4
MF:C2H3NO
MW:57.05
EINECS:203-469-1
Product Categories:
Mol File:107-16-4.mol
Glycolonitrile Structure
Glycolonitrile Chemical Properties
Melting point -72°C
Boiling point 183°C
density 1.076 g/mL at 20 °C
refractive index n20/D 1.389
Fp 133 °F
Water Solubility >=10 g/100 mL at 20 ºC
Stability:Stable, but may react violently with alkalies. Incompatible with strong oxidizing agents.
CAS DataBase Reference107-16-4(CAS DataBase Reference)
NIST Chemistry ReferenceAcetonitrile, hydroxy-(107-16-4)
EPA Substance Registry SystemAcetonitrile, hydroxy-(107-16-4)
Safety Information
Hazard Codes T+
Risk Statements 26/27/28
Safety Statements 36/37/39-45-36/37-28
RIDADR UN 3276 6.1/PG 1
WGK Germany -
RTECS AM0350000
HazardClass 6.1(a)
PackingGroup I
Hazardous Substances Data107-16-4(Hazardous Substances Data)
MSDS Information
ProviderLanguage
2-Hydroxymethylnitrile English
SigmaAldrich English
Glycolonitrile Usage And Synthesis
Chemical Propertieslight yellow liquid (typically available as a concentrated
Chemical PropertiesFormaldehyde cyanohydrin is a colorless, odorless, oily liquid. Sweet taste (very highly toxic; do not test).
UsesSolvent and organic intermediate.
General DescriptionOdorless colorless oil with a sweetish taste. Used in the manufacture of intermediates in pharmaceutical production, as a component of synthetic resins, as a chemical intermediate for organic compounds, and as a solvent.
Air & Water ReactionsWater soluble.
Reactivity ProfileGlycolonitrile may undergo spontaneous and violent decomposition. Traces of alkali (base) promote violent polymerization [Lewis].
HazardToxic by ingestion, inhalation, and skin absorption.
Health HazardExtremely toxic, exposure by any route should be avoided; may have fatal consequences; death from asphyxiation may occur similar to that resulting from hydrogen cyanide.
Fire HazardModerate explosion hazard when exposed to heat or by spontaneous chemical reaction in the presence of alkalies if uninhibited. When heated to decomposition, Glycolonitrile emits highly toxic fumes of cyanide and nitrogen oxides. Unstable, may explode on standing. Hazardous polymerization may occur. avoid the presence of alkalis, and exposure to heat.
Potential ExposureFormaldehyde cyanohydrin is used in the manufacture of intermediates in pharmaceutical produc tion and as a component of synthetic resins as a chemical intermediate for organic compounds, and as a solvent.
First aidIf this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Speed in removing material from skin is of extreme importance. Seek medical attention immedi ately. If this chemical has been inhaled, remove from expo sure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit. Keep victim quiet and maintain normal body temperature. Effects may be delayed; keep victim under observation. Use amyl nitrate capsules if symptoms develop. All area employ ees should be trained regularly in emergency measures for cyanide poisoning and in CPR. A cyanide antidote kit should be kept in the immediate work area and must be rapidly available. Kit ingredients should be replaced every 1 2 years to ensure freshness. Persons trained in the use of this kit; oxygen use, and CPR must be quickly available.
ShippingUN3276 Nitriles, liquid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required, Potential Inhalation Hazard (Special Provision 5). UN2810 Toxic liquids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.
IncompatibilitiesIncompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explo sions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, and exposure to heat. Unless stabilized with a weak acid solution, traces of alka lis may cause violent polymerization.
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