Benzamide, 2-chloro-N-(4',6-dimethoxy[1,1'-biphenyl]-3-yl)-4-fluoro-

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Benzamide, 2-chloro-N-(4',6-dimethoxy[1,1'-biphenyl]-3-yl)-4-fluoro- manufacturers

  • GSK1733953A
  • GSK1733953A pictures
  • $29.00
  • 2026-09-10
  • CAS:930470-97-6
  • Purity: 99.94%
  • Supply Ability: 10g
Benzamide, 2-chloro-N-(4',6-dimethoxy[1,1'-biphenyl]-3-yl)-4-fluoro- Basic information
Product Name:Benzamide, 2-chloro-N-(4',6-dimethoxy[1,1'-biphenyl]-3-yl)-4-fluoro-
Synonyms:Benzamide, 2-chloro-N-(4',6-dimethoxy[1,1'-biphenyl]-3-yl)-4-fluoro-;GSK1733953A;DG70;2-Chloro-N-(4',6-dimethoxy-[1,1'-biphenyl]-3-yl)-4-fluorobenzamide;2-Chloro-N-(4',6-dimethoxy-[1,1'-biphenyl]-3-yl)-4-fluorobenzamide
CAS:930470-97-6
MF:C21H17ClFNO3
MW:385.82
EINECS:
Product Categories:
Mol File:930470-97-6.mol
Benzamide, 2-chloro-N-(4',6-dimethoxy[1,1'-biphenyl]-3-yl)-4-fluoro- Structure
Benzamide, 2-chloro-N-(4',6-dimethoxy[1,1'-biphenyl]-3-yl)-4-fluoro- Chemical Properties
Boiling point 452.1±45.0 °C(Predicted)
density 1.295±0.06 g/cm3(Predicted)
form Solid
pka11.26±0.70(Predicted)
color Yellow to brown
Safety Information
MSDS Information
Benzamide, 2-chloro-N-(4',6-dimethoxy[1,1'-biphenyl]-3-yl)-4-fluoro- Usage And Synthesis
UsesDG70 (GSK1733953A), a biphenyl amide, is a respiration inhibitor in Mycobacterium tuberculosis, inhibits MenG activity with an IC50 value of 2.6 ± 0.6 μM. DG70 inhibits the catalytic methylation of Mycobacterium tuberculosis demethylmenaquinone methyltransferase enzymes. DG70 can be used for Tuberculosis (TB) research[1][2][3].
References[1] Pujari V, et al. Mycobacterial MenG: Partial Purification, Characterization, and Inhibition. ACS Infect Dis. 2022 Dec 9;8(12):2430-2440. DOI:10.1021/acsinfecdis.2c00190
[2] Adewumi AT, et al. Thompson loop: opportunities for antitubercular drug design by targeting the weak spot in demethylmenaquinone methyltransferase protein. RSC Adv. 2020 Jun 19;10(39):23466-23483. DOI:10.1039/d0ra03206a
[3] Sukheja P, et al. A Novel Small-Molecule Inhibitor of the Mycobacterium tuberculosis Demethylmenaquinone Methyltransferase MenG Is Bactericidal to Both Growing and Nutritionally Deprived Persister Cells. mBio. 2017 Feb 14;8(1):e02022-16. DOI:10.1128/mBio.02022-16
Benzamide, 2-chloro-N-(4',6-dimethoxy[1,1'-biphenyl]-3-yl)-4-fluoro- Preparation Products And Raw materials
Tag:Benzamide, 2-chloro-N-(4',6-dimethoxy[1,1'-biphenyl]-3-yl)-4-fluoro-(930470-97-6) Related Product Information
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