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Product Name:(+)-MK 801
CAS:70449-94-4
Purity:98% HPLC Package:100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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BOC Sciences
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Product Name:(+)-MK 801
CAS:70449-94-4
Remarks:Reach out to us for more information about custom solutions.
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Shanghai Chaolan Chemical Technology Center
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Product Name:Dizocilpinum,Dizocilpina,10,11-dihydro-5-methyl-5H-dibenzocyclohepten-5,10-imine,DIZOCILPINE
CAS:70449-94-4
Purity:98 Package:1G,5G,10G,50G,100G,500G
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| | 10,11-dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-imine Basic information |
| Product Name: | 10,11-dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-imine | | Synonyms: | 10,11-dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-imine;5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine;5-Methyl-5,11-epimino-10,11-dihydro-5H-dibenzo[a,d]cycloheptene;5-Methyl-10,11-dihydro-5H-5,10-epiminodibenzo[a,d][7]annulene;(+)-MK 801;5H-Dibenzo[a,d]cyclohepten-5,10-imine, 10,11-dihydro-5-methyl-;Dizocilpinum,Dizocilpina,10,11-dihydro-5-methyl-5H-dibenzocyclohepten-5,10-imine,DIZOCILPINE;">cyclohepten-5,10-imine,DIZOCILPINE | | CAS: | 70449-94-4 | | MF: | C16H15N | | MW: | 221.3 | | EINECS: | 274-609-7 | | Product Categories: | | | Mol File: | 70449-94-4.mol | ![10,11-dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-imine Structure](CAS/GIF/70449-94-4.gif) |
| | 10,11-dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-imine Chemical Properties |
| Boiling point | 320.3±11.0 °C(Predicted) | | density | 1.144±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | insoluble in H2O; ≥10.45 mg/mL in DMSO; ≥102.6 mg/mL in EtOH | | form | oil | | pka | 7.96±0.40(Predicted) | | color | brown | | InChI | InChI=1S/C16H15N/c1-16-13-8-4-2-6-11(13)10-15(17-16)12-7-3-5-9-14(12)16/h2-9,15,17H,10H2,1H3 | | InChIKey | LBOJYSIDWZQNJS-UHFFFAOYSA-N | | SMILES | C12=CC=CC=C1C1(C)NC(C2)C2=CC=CC=C12 |
| | 10,11-dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-imine Usage And Synthesis |
| Uses | (Rac)-Dizocilpine ((Rac)-MK-801) is the racemate of Dizocilpine (HY-15084B). Dizocilpine (MK-801), a potent anticonvulsant, is a selective and non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist[1]. | | Biological Activity | (+)-mk 801 is a potent antagonist of nmda with ki value of 30.5nm [1].mk 801 is a potent anticonvulsant exhibits both anxiolytic and sympathomimetic properties. it is found to be a noncompetitive antagonist of nmda. mk 801 can penetrate into the central nervous system. in the in vitro assay, mk 801 binds to rat cerebral cortical membrane with high affinity in a saturable manner. this binding is reversible even when the concentration of mk 801 is up to 100μm. it is also found that the binding shows a regional specificity. most of these binding sites are located in the hippocampus. in rat cortical-slice preparations, mk 801 causes a potent blockade of depolarizing responses to nmda with a high selectivity. this effect is persistent. the blockade can also cause a suppression of the epileptiform activity induced by tetrodotoxin or other neurotoxin [1]. | | target | NMDA | | references | [1] wong eh, kemp ja, priestley t, knight ar, woodruff gn, iversen ll . the anticonvulsant mk-801 is a potent n-methyl-d-aspartate antagonist. proc natl acad sci u s a. 1986 sep;83(18):7104-8. |
| | 10,11-dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-imine Preparation Products And Raw materials |
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