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ChemicalBook Optimization Suppliers |
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| 融点 | 86-89 °C (lit.) | | 沸点 | 273.17°C (rough estimate) | | 比重(密度) | 1.2023 (rough estimate) | | 屈折率 | 1.5810 (estimate) | | 貯蔵温度 | Keep in dark place,Sealed in dry,Room Temperature | | 溶解性 | Chloroform (Slightly), Methanol (Slightly) | | 酸解離定数(Pka) | 13.42±0.50(Predicted) | | 外見 | Powder or Flakes | | 色 | Off-white to light beige | | 水溶解度 | 68.02g/L(37 ºC) | | BRN | 1865635 | | InChIKey | PUJDIJCNWFYVJX-UHFFFAOYSA-N | | CAS データベース | 621-84-1(CAS DataBase Reference) | | NISTの化学物質情報 | Carbamic acid, benzyl ester(621-84-1) |
| | カルバミン酸ベンジル Usage And Synthesis |
| 外観 | 白色～うすい褐色、結晶～結晶性粉末 | | 用途 | 有機合成原料。 | | 化学的特性 | Off-white to light beige powder or flakes, melting point 87-89 ℃. Insoluble in water, soluble in organic solvents such as benzene. | | 主な応用 | Benzyl carbamate is an intermediate in the synthesis of various pharmaceutical compounds. It can be also used as nondeuterated internal standards for the quantitative analysis of carisoprodol in blood. | | 使用 | Benzyl carbamate is a reagent used for the nucleophilic introduction of an amino-protected group, Benzyl carbamates can be considered as a benzyloxycarbonyl (otherwise known as carbobenzyloxy, Cbz or Z) protecting group for amino groups. It was introduced as a versatile alternative to the ethoxy carbamate group in peptide synthesis. | | 製造方法 | Benzyl carbamate is prepared by reacting benzyl chloroformate with ammonia. Benzyl chloroformate was slowly added to 5 times the volume of cold ammonia water (relative density 0.90) under vigorous stirring, the reaction mixture was placed at room temperature for 30 minutes, the precipitate was filtered out, washed with water and dried to obtain the finished product of benzyl carbamate. | | 純化方法 | If it smells of NH3, then dry it in a vacuum desiccator and recrystallise it from 2 volumes of toluene and dry it in a vacuum desiccator again. It forms glistening plates from toluene, and can be recrystallised from H2O [Martell & Herbst J Org Chem 6 878 1941, Carter et al. Org Synth Coll Vol III 168 1955]. [Beilstein 6 IV 2278.] |
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