| Company Name: |
LGM Pharma
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| Tel: |
1-(800)-881-8210 |
| Email: |
inquiries@lgmpharma.com |
| Products Intro: |
Product Name:Sorivudine
CAS:77181-69-2
Purity:Typically NLT 98%
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| Company Name: |
Changzhou PBpharmaceutical R&D Co.,Ltd
|
| Tel: |
0519-83990708 |
| Email: |
lxy2046@yeah.net |
| Products Intro: |
Product Name:sorivudine
CAS:77181-69-2
Purity:95% Package:1g,5g,10g,25g,100g,500g,1kg,5kg,25kg
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| | sorivudine Basic information |
| Product Name: | sorivudine | | Synonyms: | sorivudine;1-(β-D-Arabinofuranosyl)-5-[(E)-2-bromoethenyl]uracil;1-β-D-Arabinofuranosyl-5-[(E)-2-bromovinyl]-1,2,3,4-tetrahydropyrimidine-2,4-dione;Brovavir;BvAraU;BV-araU;YN-72;Bravavir | | CAS: | 77181-69-2 | | MF: | C11H13BrN2O6 | | MW: | 349.13 | | EINECS: | | | Product Categories: | | | Mol File: | 77181-69-2.mol |  |
| | sorivudine Chemical Properties |
| Melting point | 182° (Sakata, 1980); mp 195-200° (dec) (Machida, Sakata, 1983) | | alpha | D25 +0.5° (1N NaOH) | | density | 1.979±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 250 mg/mL (716.07 mM) | | pka | 8.37±0.10(Predicted) |
| Toxicity | LD50 in mice (mg/kg): ~3300 i.p.; >5000 s.c.; >10000 orally (Machida, Sakata, 1984) |
| | sorivudine Usage And Synthesis |
| Description | Sorivudine is an orally-active antiviral nucleoside analog. It has potent and selective
activity against herpes simplex virus type-1 (HSV-1) and varicella-zoster virus (VZV). In a
cutaneous model infection of mice with HSV-1, oral administration of sorivudine at dose of
20 mg/kg resulted in a significant increase in the survival rate. Five percent sorivudine cream
is also useful in the topical treatment of cutaneous HSV-1 infection, including
immunocompromised patients. It has been suggested that its antiviral activity may be
mediated by inhibition of DNA synthesis in virus infected cells.
Since the metabolite of sorivudine inhibits the enzyme for pyrimidine catabolism,
caution should be taken not to use sorivudine in combination with fluorouracil drugs in order to
avoid hematological disorders. | | Originator | Yamasa Shoyu (Japan) | | Uses | Sorivudine is an antimetabolite drug and can be used to synthesize antiviral compounds as well as compounds that can treat diseases of viral etiol. | | Uses | Antiviral. | | Definition | ChEBI: Sorivudine is an organic molecular entity. | | Brand name | Bravavir (Bristol-Myers Squibb);Usevir. |
| | sorivudine Preparation Products And Raw materials |
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