| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:SMA-12b
CAS:1496553-39-9
Purity:99.10% Package:1mg/RMB 1980;5mg/RMB 4920;10mg/RMB 7130
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Ethanaminium, N,N,N-trimethyl-2-[[(4-methylphenyl)methyl]sulfonyl]-, iodide (1:1) manufacturers
- SMA-12b
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- $293.00 / 1mg
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2025-11-10
- CAS:1496553-39-9
- Min. Order:
- Purity: 99.16%
- Supply Ability: 10g
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| | Ethanaminium, N,N,N-trimethyl-2-[[(4-methylphenyl)methyl]sulfonyl]-, iodide (1:1) Basic information |
| | Ethanaminium, N,N,N-trimethyl-2-[[(4-methylphenyl)methyl]sulfonyl]-, iodide (1:1) Chemical Properties |
| | Ethanaminium, N,N,N-trimethyl-2-[[(4-methylphenyl)methyl]sulfonyl]-, iodide (1:1) Usage And Synthesis |
| Description | SMA-12b is an inhibitor of IL-1. | | Uses | SMA-12b is a small molecule analogue of the parasitic worm compound ES-62. SMA-12b has immunomodulatory activity, acting by regulating the expression of multiple inflammatory response genes, especially those associated with inflammatory bodies. SMA-12b significantly reduces the expression of cytokine IL-1β associated with inflammatory bodies and inhibites the production of IL-1β through a mechanism mediated by NRF2. SMA-12b can be used in the study of rheumatoid arthritis (RA) and other autoimmune diseases[1]. | | References | [1] Rzepecka J, et al. Prophylactic and therapeutic treatment with a synthetic analogue of a parasitic worm product prevents experimental arthritis and inhibits IL-1β production via NRF2-mediated counter-regulation of the inflammasome[J]. Journal of autoimmunity, 2015, 60: 59-73. DOI:10.1016/j.jaut.2015.04.005 |
| | Ethanaminium, N,N,N-trimethyl-2-[[(4-methylphenyl)methyl]sulfonyl]-, iodide (1:1) Preparation Products And Raw materials |
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