| Company Name: |
Jiangsu Hongmin Pharmaceutical Co., Ltd.
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| Tel: |
18221292452 |
| Email: |
fannieliu@glschina.com |
| Products Intro: |
Product Name:N-[6-Oxopiperidin-2(S)-Ylcarbonyl]-L-Leucyl-L- Prolinamide
CAS:78664-73-0
Purity:0.95 Package:g;kg
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| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:Posatirelin
CAS:78664-73-0
Purity:98.22% Package:1 mg；5 mg；100 mg；25 mg；10 mg；50 mg；
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| Company Name: |
CLEARSYNTH LABS LTD.
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| Tel: |
+91-22-45045900 |
| Email: |
sales@clearsynth.com |
| Products Intro: |
Product Name:Posatirelin
CAS:78664-73-0
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| Company Name: |
United States Biological
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| Tel: |
800.520.3011 or 781.639.5092 |
| Email: |
chemicals@usbio.net |
| Products Intro: |
Product Name:Posatirelin
CAS:78664-73-0
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| Product Name: | Posatirelin | | Synonyms: | Posatirelin;N-[(S)-6-Oxo-2-piperidinylcarbonyl]-L-Leu-L-Pro-NH2;RGH-2202;N-[6-Oxopiperidin-2(S)-Ylcarbonyl]-L-Leucyl-L- Prolinamide;BRN 6006446;BRN6006446;BRN-6006446;Posatirelinum | | CAS: | 78664-73-0 | | MF: | C17H28N4O4 | | MW: | 352.432 | | EINECS: | | | Product Categories: | | | Mol File: | 78664-73-0.mol |  |
| | Posatirelin Chemical Properties |
| Melting point | 214-216° | | alpha | D25 -80.2° (c = 1 in acetic acid) | | Boiling point | 739.6±60.0 °C(Predicted) | | density | 1.214±0.06 g/cm3(Predicted) | | pka | 13.56±0.20(Predicted) |
| | Posatirelin Usage And Synthesis |
| Pharmacological Study | Posatirelin is a TRH analogue. In a rat experimental model
of brain cholinergic deficit by lesion of the nucleus basalis
magnocellularis (nbM), posatirelin treatment rescued
cholinergic neurones of the nbM and their cholinergic
projections to the cerebral cortex (Sabbatini et al., 1998).
Posatirelin has been used in AD and VaD patients (Parnetti
et al., 1995, 1996). VaD patients treated with posatirelin
showed a significant improvement in intellectual performance,
orientation, motivation and memory as compared
to controls. The drug was well tolerated. | | Description | Posatirelin is a TRH analogue. In a rat experimental model of brain cholinergic decit by lesion of the nucleus basalis magnocellularis (nbM), posatirelin treatment rescued cholinergic neurones of the nbM and their cholinergic projections to the cerebral cortex (Sabbatini et al., 1998). Posatirelin has been used in AD and VaD patients (Parnetti et al., 1995, 1996). VaD patients treated with posatirelin showed a signicant improvement in intellectual performance, orientation, motivation and memory as compared to controls. e drug was well tolerated. | | Uses | Posatirelin is a thyrotropin-releasing hormone analogue, used in the treatment of seizures and some neurodegenerative disease such as vascular dementia and Parkinson''s disease. | | Definition | ChEBI: Posatirelin is an oligopeptide. |
| | Posatirelin Preparation Products And Raw materials |
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