Robalzotan manufacturers
- Robalzotan
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- $1970.00
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2026-05-11
- CAS:169758-66-1
- Purity:
- Supply Ability: 10g
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| | Robalzotan Basic information |
| Product Name: | Robalzotan | | Synonyms: | Robalzotan;Robalzotan [inn];Unii-I18m56ogme;(3R)-3-(Dicyclobutylamino)-8-fluoro-3,4-dihydro-2H-1-benzopyran-5-carboxamidehydrochloride;NAD 299;(R)-3-(DicyclobutylaMino)-8-fluorochroMan-5-carboxaMide;NAD 299 hydrochloride (Robalzotan);NAD 299 hydrochloride | | CAS: | 169758-66-1 | | MF: | C18H23FN2O2 | | MW: | 318.39 | | EINECS: | | | Product Categories: | | | Mol File: | 169758-66-1.mol |  |
| | Robalzotan Chemical Properties |
| Boiling point | 429.9±45.0 °C(Predicted) | | density | 1.27±0.1 g/cm3(Predicted) | | storage temp. | Desiccate at RT | | pka | 15.72±0.40(Predicted) |
| | Robalzotan Usage And Synthesis |
| Uses | NAD 299 Hydrochloride is a selective, high affinity 5-HT1A antagonist, used in psychotropic drug development. | | Biological Activity | Selective, high affinity 5-HT 1A receptor antagonist (K i = 0.6 nM in vitro ). | | in vivo | Robalzotan (1-100 μg/kg; i.v.) significantly increases the activity of such neurons at 5 μg/kg in rats, and reverses the acute inhibitory effect of citalopram (HY-121203) (300 μg/kg i.v.) or paroxetine (HY-122272) (100 μg/kg, i.v.) on the activity of 5-HT neurons in the dorsal raphe nucleus in rats[1].
Robalzotan (5, 50 μg/kg; i.v.) increases the firing rate of the 5-HT cells[1].
Robalzotan (2-100 μg/kg; i.v.) occupies 5-HT1A receptors in a dose-dependent in monkeys[2].
Robalzotan (0.3; 1 and 3 μmol/kg s.c) causes a dose-dependent increase of extracellular ACh levels in the rat FC[3]. | | IC 50 | 5-HT1A Receptor |
| | Robalzotan Preparation Products And Raw materials |
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