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ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate

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ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:EBPC
CAS:4450-98-0
Package:1 mg；10 mg；100 mg；200 mg；25 mg；5 mg；50 mg；500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Hangzhou MolCore BioPharmatech Co.,Ltd.
Tel: +86-057181025280; +8617767106207
Email: sales@molcore.com
Products Intro: Product Name:EBPC
CAS:4450-98-0
Purity:NLT 98% Remarks:MC555080
Company Name: J & K SCIENTIFIC LTD.  
Tel: 010-82848833 400-666-7788
Email: jkinfo@jkchemical.com
Products Intro: Product Name:EBPC
CAS:4450-98-0
Purity:95+% Package:100Mg,10Mg
Company Name: Tetranov Biopharm  
Tel: 13526569071
Email: sales@leadmedpharm.com
Products Intro: Product Name:ethyl 1-benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylate
CAS:4450-98-0
Purity:95% Package:1g;5g;25g;100g
Company Name: Chemsky（shanghai）International Co.,Ltd.  
Tel: 021-50135380
Email: shchemsky@sina.com
Products Intro: Product Name:EBPC
CAS:4450-98-0
Purity:98%
ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate Basic information
Product Name:ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate
Synonyms:1-Ebpc;1H-Pyrrole-3-carboxylic acid, 2,5-dihydro-4-hydroxy-5-oxo-1-(phenylmethyl)-, ethyl ester;Nsc 229530;1-Benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester;1-Benzyl-4-bydroxy-5-oxo-3-pyrroline-3-carboxylic Acid Ethyl Ester;2,5-Dihydro-4-hydroxy-5-oxo-1-(phenylMethyl)-1H-pyrrole-3-carboxylic Acid Ethyl Ester;CP-10668;Aldose Reductase,inhibit,EBPC,Inhibitor
CAS:4450-98-0
MF:C14H15NO4
MW:261.27
EINECS:
Product Categories:Aromatics;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pfizer Compounds;Pharmaceuticals
Mol File:4450-98-0.mol
ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate Structure
ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate Chemical Properties
Melting point 135-136 °C
Boiling point 479.8±45.0 °C(Predicted)
density 1.340±0.06 g/cm3(Predicted)
storage temp. room temp
solubility DMSO: ≥10mg/mL
form white powder
pka4.50±1.00(Predicted)
Safety Information
Hazard Codes Xn
Risk Statements 22-41
Safety Statements 26
WGK Germany 3
HazardClass IRRITANT
MSDS Information
ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate Usage And Synthesis
DescriptionThe human aldose reductase AKR1B1 is considered the rate limiting enzyme of the polyol pathway responsible for the conversion of glucose into sorbitol. It also acts as a highly efficient PGF2α synthase in response to interleukin-1β. Increased aldose reductase expression has been associated with complications of diabetes and may contribute to reduced efficacy of certain chemotherapeutic drugs. EBPC is a potent, selective inhibitor of aldose reductase with an IC50 value of 47 nM in vitro. Through its regulation of glucose metabolism, EBPC has been used to improve the cytotoxic effects of the anticancer agents doxorubicin and cisplatin in HeLa cervical carcinoma cells. EBPC also inhibits prostaglandin F2α (PGF2α) and PGE2 production in human endometrial cells with an EC50 value of 10 μM.
UsesA highly specific aldose reductase inhibitor that has been shown to enhance HeLa cell sensitivity to chemotherapeutic drugs.
DefinitionChEBI: Ethyl 1-benzyl-3-hydroxy- 2-oxo[5H]pyrrole-4-carboxylate is a pyrroline and a carboxylic acid.
ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate Preparation Products And Raw materials
Tag:ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate(4450-98-0) Related Product Information
1-BENZYL-1,5-DIHYDRO-PYRROL-2-ONE Ethyl 3-(benzylamino)propanoate 1-Benzyl-2,5-dihydro-1H-pyrrole 1-(4-Methoxybenzyl)-3-hydroxy-4-ethoxycarbonyl-5-(3-pyridyl)-3-pyrrolin-2-one ETHYL 3-(N-BENZYL-N-METHYLAMINO)PROPANOATE 1-BENZYL-2,5-DIHYDRO-1H-PYRROLE-3-CARBOXYLIC ACID METHYL ESTER ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate