CVT 313
中文名称 | CVT 313 |
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中文同义词 | CDK2抑制剂(CVT-313);CVT-313游离态;化合物CVT313;2,2'-((9-异丙基-6-((4-甲氧基苄基)氨基)-9H-嘌呤-2-基)氮烷二基)二乙醇;2,2'-((9-异丙基-6-((4-甲氧基苄基)氨基)-9H-嘌呤-2-基)氮烷二基)二乙醇;CVT-313,CDK2抑制剂 |
英文名称 | 2(BIS-(HYDROXYETHYL)AMINO)-6-(4-METHOXYBENZYLAMINO)-9-ISOPROPYL-PURINE |
英文同义词 | CVT-313;CDK2 INHIBITOR III;2(BIS-(HYDROXYETHYL)AMINO)-6-(4-METHOXYBENZYLAMINO)-9-ISOPROPYL-PURINE;Anti-ABHD16A antibody produced in rabbit;BAT5;D6S82E;2,2'-(9-isopropyl-6-(4-methoxybenzylamino)-9H-purin-2-ylazanediyl)diethanol;CVT-313(NG-26) |
CAS号 | 199986-75-9 |
分子式 | C20H28N6O3 |
分子量 | 400.47 |
EINECS号 | |
相关类别 | 细胞生物学试剂 |
Mol文件 | 199986-75-9.mol |
结构式 |
CVT 313 性质
沸点 | 652.3±65.0 °C(Predicted) |
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密度 | 1.30±0.1 g/cm3(Predicted) |
储存条件 | Sealed in dry,Store in freezer, under -20°C |
溶解度 | DMSO 中≥20 mg/mL;不溶于水;温和加热时,EtOH 中≥51.1 mg/mL |
形态 | 白色固体 |
酸度系数(pKa) | 13.95±0.10(Predicted) |
颜色 | 白色至米白色 |
InChIKey | NQVIIUBWMBHLOZ-UHFFFAOYSA-N |
Target | Value |
CDK2
(Cell-free assay) | 0.5 μM |
CVT-313 (Cdk2 Inhibitor III) has been shown to inhibit other kinases, but at much higher IC 50 values, i.e., CDK1 (IC 50 =4.2 μM), CDK4 D1 (IC 50 =215 μM), and MAPK/PKA/PKC (IC 50 >1.25 mM), compared to CDK2 (IC 50 =0.5 μM). CVT-313 has been shown to have profound effects on cell proliferation at concentrations of 5-20 μM. CVT-313 is a potent CDK2 inhibitor, which is identified from a purine analog library with an IC 50 of 0.5 μM in vitro. Inhibition is competitive with respect to ATP (K i =95 nM), and selective CVT-313 has no effect on other, nonrelated ATP-dependent serine/threonine kinases. When added to CDK1 or CDK4, a 8.5- and 430-fold higher concentration of CVT-313 is required for half-maximal inhibition of the enzyme activity. Using normal and tumor human/murine cell lines, the effects of CVT-313 on cell proliferation is measured. The IC 50 for growth inhibition ranged from 1.25 to 20 μM.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/08/19 | HY-15339 | CVT-313 | 1 mg | 341元 | |
2024/08/19 | HY-15339 | CVT 313 CVT-313 | 199986-75-9 | 5mg | 818元 |