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| 融点 | ≥300 °C(lit.) | | 沸点 | 528.5±52.0 °C(Predicted) | | 比重(密度) | 1.9571 | | 溶解性 | Sparingly soluble in water, soluble in concentrated mineral acids, alkali
carbonate solutions, alcohol and diethyl ether. Practically insoluble in
acetone, benzene and chloroform. | | 外見 | solid | | 酸解離定数(Pka) | pK1: ca 2;pK2: 4.02;pK3: 8.62 (25°C) | | 色 | Needles from aq solns | | 水溶解度 | SLIGHTLY SOLUBLE IN COLD WATER | | Merck | 14,792 | | BRN | 1102334 | | 安定性： | Hygroscopic | | InChIKey | XKNKHVGWJDPIRJ-UHFFFAOYSA-N | | CAS データベース | 98-50-0(CAS DataBase Reference) | | EPAの化学物質情報 | p-Aminobenzenearsonic acid (98-50-0) |
| | 4-アミノフェニルアルソン酸 Usage And Synthesis |
| 外観 | 白色～わずかにうすい黄色, 結晶性粉末～粉末 | | 溶解性 | 熱水, メタノールに易溶。エタノール, 氷酢酸に難溶。エーテル, アセトン, ベンゼン, クロロホルムに不溶。熱水及び塩酸に溶け、アセトンにほとんど溶けない。 | | 解説 | 4-アミノフェニルアルソン酸,無色の針状晶．融点232 ℃．熱水から再結晶すると二水和物が得られるが，150 ℃ 以上で無水物となる．メタノールに易溶．ヒ素系医薬の製造原料となるほか，ジルコニウム，セリウムなどの検出試薬として使われる． 森北出版「化学辞典（第2版） | | 用途 | 亜硝酸の検出、医薬原料。 | | 効能 | 抗菌薬 (獣医薬) | | 化学的特性 | p-Arsanilic acid is an off-white powder. It is slightly soluble in cold water. It is incompatible
with oxidizing agents; on hazardous decomposition, p-arsanilic acid produces nitrogen
oxides, carbon monoxide, carbon dioxide, nitrogen gas, and oxides of arsenic. | | 化学的特性 | off-white fine crystalline powder | | Originator | Arsanilic acid,Fleming Laboratories, Inc. | | 使用 | Arsanilic acid reacts essentially analogously to phenylarsonic acid. According to Chandelle, in the presence of relatively large amounts of accompanying ions the determination of zirconium gives more accurate results with this reagent than with phenylarsonic acid. This statement has not yet been confirmed. Nevertheless, the reagent is much more widely used than any other arsonic acid derivative. | | 使用 | 4-Aminophenylarsonic acid is an organoarsenic compound. 4-Aminophenylarsonic acid is a highly toxic contaminant and can be found in plants growing in contaminated soil. 4-Aminophenylarsonic acid was used as an additive in animal feed. It has also been used in treating dysentery in swine as well as having potential chemotherapeutic activity. | | 使用 | manufacture of medicinal arsenicals. | | 定義 | ChEBI: Arsanilic acid is an organoarsonic acid. It is a conjugate acid of an arsanilate(1-). | | Manufacturing Process | 342.0 g (2 mol) of 83% arsenic acid were added during 75 min to a rapidly
stirred mixture of 372.5 g (4 mol) aniline and 111.0 g chlorobenzene while
the temperature of the mixture was kept at 147°-150°C. After the addition of
arsenic acid was complete the mixture was stirred for an additional 8 h while
being maintained at 149°-153°C. Water was continuously removed by
distillation, and the organic phase of the distillate was continuously recycled back into the reaction mixture. At the end of that time a total of 121.0 g of
water, containing the condensation of aniline and arsenic acid has been
removed. The mixture was then allowed to cool to 110°C. 562.0 g (2.81 mol)
of 20% sodium hydroxide were added over a 2 h period while water,
chlorobenzene and excess aniline were distilled off at a temperature of from
102°-113°C. The distillation was continued for an additional 2 h while the
volume of the mixture was kept at about 700 ml by the addition of water.
The mixture was then diluted with water to a volume of 1400 ml and allowed
to cool to 23°C. At this point, 52.0 g of by-product material, which was
predominantly tri-(p-aminophenyl)-arsineoxide, were filtered out. The pH of
the filtrate was then brought from 8.7 to 5.1 by the addition of 1.8 mol of
hydrochloric acid while the volume of the mixture was increased to 2,200 ml
by the addition of water. The mixture was stirred for 5 h at room temperature
and again filtered. 108.0 g of by-product material comprising predominantly
di-(p-aminophenyl)-arsinic acid was filtered off at this point.
The pH of the filtrate was lowered to 4.5 by the addition of 0.2 mole of
hydrochloric acid, and an additional 5.0 g of by-products, the composition of
which was not determined, was filtered off. The filtrate was then brought to a
pH of 3.2 by addition of 0.6 mole of hydrochloric acid, and 128.0 g (29.5%
based upon arsenic acid) of arsanilic acid were recovered as a precipitate.
The arsanilic acid filtrate was combined with the by-products filtered off during
each of the three filtration steps. 2.8 mol of hydrochloric acid were added to
the combined arsanilic acid filtrate and the mixture was heated at 80°C for 5
days. Arsanilic acid was then precipitated from the remaining hydrolyzed
mixture in the manner described for the primary reaction product, and an
additional 120.0 g (27.5% based on arsenic acid) were recovered. The filtrate
contained 14.0 g (3.2%) of arsanilic acid which could be recovered at least
partially in subsequent processing. Thus it can be seen from this example that
an arsanilic acid yield of 59% was obtained. | | Therapeutic Function | Antibacterial | | 危険性 | Toxic. | | 健康ハザード | Occupational workers exposed to p-arsanilic acid develop poisoning. The symptoms
include, but are not limited to, eye and skin irritation, chemical conjunctivitis and corneal
damage, hyperpigmentation of the skin and, perkeratoses of plantar and palmar surfaces,
primary irritation and sensitization, digestive tract irritation, gastrointestinal hypermotility, diarrhea, hepatitis, hepatocellular necrosis, central nervous system depression, cardiac
disturbances, and liver and kidney damage. The target organs include the kidneys, central
nervous system, liver, and cardiovascular system. After a prolonged period of exposure
to arsenic compounds, including arsenical dust, workers are known to develop shortness
of breath, nausea, chest pains, garlic odor, and impairment of peripheral circulation. The
toxicological properties of p-arsanilic acid have not been fully investigated. | | 安全性プロファイル | Poison by intravenous
and intraperitoneal routes. Moderately toxic
by ingestion. Flammable, decomposes with heat to yield flammable vapors. When
heated to decomposition or on contact with
acid or acid fumes it emits highly toxic
fumes of As and NO,. See also ARSENIC
COMPOUNDS and ANILINE. | | 貯蔵 | p-Arsanilic acid should be kept stored in a tightly closed container in a cool, dry, wellventilated area. It should be kept away from incompatible materials, dust generation,
excess heat, and strong oxidants. | | 純化方法 | Crystallise it from water or ethanol/ether. POISONOUS. [Beilstein 16 I 466.] | | 予防処置 | Occupational workers should wash thoroughly after using p-arsanilic acid. Any contaminated clothing should be washed before reuse. Work areas should have adequate ventilation and minimum dust generation and accumulation. Workers should avoid any
kind of contact of p-arsanilic acid with the eyes, skin, clothing, ingestion or inhalation. |
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