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| 化学名: | 4-イソプロピルアンチピリン | | 英語化学名: | Propyphenazone | | 别名: | 2,3-dimethyl-4-isopropyl-1-phenyl-3-pyrazolin-5-on;3H-Pyrazol-3-one, 1,2-dihydro-1,5-dimethyl-4-(1-methylethyl)-2-phenyl-;3H-Pyrazol-3-one,1,2-dihydro-1,5-dimethyl-4-(1-methylethyl)-2-phenyl-;3-Pyrazolin-5-one, 2,3-dimethyl-4-isopropyl-1-phenyl-;4-ISOPROPYL-2,3-DIMETHYL-1-PHENYL-5-PYRAZOLONE;2,3-Dimethyl-1-phenyl-4-isopropylpyrazolone;4-Isopropyl-2,3-dimethyl-1-phenyl-3-pyrazoline-5-on;4-ISO-PROPYL-2,3-DIMETHYL-1-PHENYL-3-PYRAZOLIN-5-ONE(PROPYPHENAZONE) | | CAS番号: | 479-92-5 | | 分子式: | C14H18N2O | | 分子量: | 230.31 | | EINECS: | 207-539-2 | | カテゴリ情報: | Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;API's;Active Pharmaceutical Ingredients | | Mol File: | 479-92-5.mol |  |
| | 4-イソプロピルアンチピリン Usage And Synthesis |
| 外観 | 白色～ほとんど白色粉末～結晶 | | 効能 | 鎮痛薬, 解熱薬 | | 商品名 | ヨシピリン (吉田製薬) | | 説明 | This uncharacterized alkaloid has been described by Hartsen as occurring in Iso_x0002_pyrum thalictroides L. No chemical or physical characteristics are known. | | 化学的特性 | solid | | 使用 | Analgesic; antipyretic; anti-inflammatory. | | 定義 | ChEBI: A pyrazolone derivative that is antipyrine substituted at C-4 by an isopropyl group. | | brand name | 539 grippe-dragees;Amipylo-n;Balpiren;Baukal;Caffalgina;Camoplex;Cantacin;Cerebrol;Daturmed;Degripol;Dentocaps a;Dim-antos;Dolibral;Dolo-mineuron;Dysmalgin;Ejcopyrin;Epizon;Escomen;Estesina;Fd 8;Febral;Finigripp;Grippocaps;Heaven;Infantex;Influvit;Isopronazon;Kavapyret;Kuronde;Lysadestat;Mamaslu;Milneuron;Myo-europan;Neuramin;Neuridal;Neuro-spondryl;Nodiras;Noric;Otobacid;Pfeil;Reomin;Retamex;Rheumanol;Rhinivict;Sanalgin-p;Saridon neu;Saridone;Sedospin;Servalgin;Sonotryl;Spalt;Spongamed;Stona;Synpyrin;Vivcet;Wauco-sin;Wecontrin. | | 世界保健機関（WHO） | Propyphenazone, a pyrazolone derivative with anti-inflammatory,
analgesic and antipyretic activity, was introduced in 1951 for the treatment of
rheumatic disorders. As it is structurally related to aminophenazone it has been
associated with severe blood dyscrasias. However, it cannot be transformed into
potentially carcinogenic nitrosamines and has therefore been widely used as a
replacement drug for aminophenazone. In certain countries, products containing
propyphenazone have now been restricted in their indications, whereas in others
they are still available, sometimes as over-the-counter preparations. See also WHO
comment for aminophenazone. | | 臨床応用 | Propyphenazone is a
derivative of phenazone and has a similar analgesic
and antipyretic action. It is used as a monocompound
as well as in multi-ingredient preparations. | | 参考文献 | Hartsen., J. Chem. Soc., 511 (1873)
Mirande., Compt. rend., 168,316 (1919) |
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