VAS2870
| 中文名称 | VAS2870 |
|---|---|
| 中文同义词 | 化合物VAS2870;2-((3-苄基-3H- [1,2,3]三唑并[4,5-D]嘧啶-7-基)硫代)苯并[D]恶唑;VAS 2870,NADPH氧化酶抑制剂 |
| 英文名称 | 1,3-benzoxazol-2-yl 3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide |
| 英文同义词 | 1,3-benzoxazol-2-yl 3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide;7-(1,3-Benzoxazol-2-ylsulfanyl)-3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidine;7-(2-Benzoxazolylthio)-3-(phenylmethyl)-3H-1,2,3-triazolo[4,5-d]pyrimidine;VAS 2870;VAS2870;VAS-2870;NOX Inhibitor III, VAS2870;2-(3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-ylthio)benzo[d]oxazole |
| CAS号 | 722456-31-7 |
| 分子式 | C18H12N6OS |
| 分子量 | 360.39 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 722456-31-7.mol |
| 结构式 |  |
VAS2870 性质
| 沸点 | 627.0±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.53±0.1 g/cm3(Predicted) |
| 储存条件 | room temp |
| 溶解度 | 二甲基亚砜：≥5mg/mL |
| 形态 | 棕褐色固体 |
| 酸度系数(pKa) | 0.85±0.30(Predicted) |
| 颜色 | 白色至米色 |
| 稳定性 | 可在-20°C下的DMSO中的溶液储存长达3个月。 |
| Target | Value |
|
NADPH oxidase
() |
VAS2870 is effective to suppress PDGF-BB-dependent activation of NADPH oxidase and subsequent production of intracellular ROS. Furthermore, VAS2870 suppresses PDGF-BB-dependent chemotaxis, but not DNA synthesis. Preincubation with VAS2870 (10 and 20 μM) completely abolishes PDGF-mediated NADPH oxidase activation and ROS production. Preincubation with VAS2870 (0.1-20 μM) does not affect PDGF-induced cell cycle progression. However, it abolishes PDGF-dependent chemotaxis of VSMC in a concentration-dependent manner (100% inhibition at 10 μM). VAS2870 inhibits dose-dependently autocrine increase of cell number in FaO rat hepatoma cells, and almost completely blocked ROS production and thymidine incorporation when used at 25 mM. VAS2870 blocks serum-dependent cell growth of FaO rat hepatoma cells. VAS2870 inhibits proliferation of different human hepatocellular carcinoma (HCC) cell lines. VAS2870 pretreatment enhances TGF-b-mediated apoptosis of FaO rat hepatoma cells.
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-12804 | VAS2870 | 1 mg | 300元 | |
| 2024/01/25 | HY-12804 | VAS2870 VAS2870 | 722456-31-7 | 5mg | 660元 |