1,3-benzoxazol-2-yl 3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide

1,3-benzoxazol-2-yl 3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
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Products Intro: Product Name:VAS2870
CAS:722456-31-7
Purity:0.99 Package:5MG;10MG;50MG;100MG,1G,5G
Company Name: BOC Sciences
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Products Intro: Product Name:VAS2870
CAS:722456-31-7
Purity:98% Package:1G;10G;100G Remarks:VAS2870 is a cell-permeable and selective inhibitor of the NADPH oxidases. It was shown to enhance apoptosis induced by a physiological stimulus, such as TGF-β, and inhibit either autocrine or serum-d
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Products Intro: Product Name:1,3-benzoxazol-2-yl 3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide
CAS:722456-31-7
Purity:99% Package:1g;1USD
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Products Intro: Product Name:VAS2870
CAS:722456-31-7
Purity:98% Package:Package as requetsed
Company Name: Target Molecule Corp
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Products Intro: Product Name:VAS2870
CAS:722456-31-7
Purity:97.49% Package:5 mg;10 mg;25 mg;50 mg;100 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
1,3-benzoxazol-2-yl 3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide Basic information
Product Name:1,3-benzoxazol-2-yl 3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide
Synonyms:1,3-benzoxazol-2-yl 3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide;7-(1,3-Benzoxazol-2-ylsulfanyl)-3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidine;7-(2-Benzoxazolylthio)-3-(phenylmethyl)-3H-1,2,3-triazolo[4,5-d]pyrimidine;VAS 2870;VAS2870;VAS-2870;NOX Inhibitor III, VAS2870;2-(3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-ylthio)benzo[d]oxazole
CAS:722456-31-7
MF:C18H12N6OS
MW:360.39
EINECS:
Product Categories:
Mol File:722456-31-7.mol
1,3-benzoxazol-2-yl 3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide Structure
1,3-benzoxazol-2-yl 3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide Chemical Properties
Boiling point 627.0±65.0 °C(Predicted)
density 1.53±0.1 g/cm3(Predicted)
storage temp. room temp
solubility DMSO: ≥5mg/mL
form Tan solid
pka0.85±0.30(Predicted)
color white to beige
Safety Information
Hazard Codes Xn
Risk Statements 22
WGK Germany 3
MSDS Information
1,3-benzoxazol-2-yl 3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide Usage And Synthesis
UsesVAS 2870, is a NADPH oxidase (NOX) inhibitor.
General Description
A cell-permeable thiotriazolopyrimidine compound that acts as an effective NADPH oxidase (NOX) inhibitor (IC50 = 10.6 μM against NOX activity in human neutrophil lysates) and is widely used for studying NOX-dependent cellular ROS formations in various cultures, including oxLDL-treated HUVEC (complete inhibition at 5 μM), PDGF-induced primary rat VSMC (vascular smooth muscle cells; complete inhibition at 10 μM), as well as aortic sections from spontaneously hypertensive rats (SHRs) (72% inhibition at 10 μM). Also shown to inhibit PDGF-BB-induced murine EB (embryonid body) vacularization (74% inhibition at 50 μM) and improve ACh-induced vasorelaxation of isolated rat aortic rings from both SHRs and non-hypertensive rats ex vivo (by 41.7 and 34.5%, respectively, at 10 μM).
1,3-benzoxazol-2-yl 3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide Preparation Products And Raw materials
Tag:1,3-benzoxazol-2-yl 3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide(722456-31-7) Related Product Information
VASA (2F9H5) PE VAP-1 (A-8) VAP-1 (E-10) DIPHENYLENEIODONIUM CHLORIDE PRODIGIOSIN