| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:15-deoxy-Δ-12,14-Prostaglandin J2;(5Z,12E,14E)-11-Oxo-prosta-5,9,12,14-tetraen-1-oicacid
CAS:87893-55-8
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| Company Name: |
NCE Biomedical Co.,Ltd.
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| Tel: |
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 |
| Email: |
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| Products Intro: |
Product Name:15D-PGJ2
CAS:87893-55-8
Purity:99% HPLC Package:100Mg, 1g, 5g,10g
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| | 15D-PGJ2 Basic information |
| Product Name: | 15D-PGJ2 | | Synonyms: | 15-deoxy-Δ12,14-Prostaglandin J2 Lipid Maps MS Standard;11-Oxoprosta-(5Z,9,12E,14E)-tetraen-1-oic acid;15-Deoxy-Δ12,14-PGJ2;15-deoxy-Δ12,14-Prostaglandin J2 solution;15d-PGJ?;15D-PGJ2;15-DEOXY-DELTA12,14-PROSTAGLANGIN J2;15-DEOXY-DELTA12,DELTA14-PROSTAGLANDIN J2 | | CAS: | 87893-55-8 | | MF: | C20H28O3 | | MW: | 316.43 | | EINECS: | 201-185-2 | | Product Categories: | | | Mol File: | 87893-55-8.mol |  |
| | 15D-PGJ2 Chemical Properties |
| Fp | -9℃ | | storage temp. | -20°C | | solubility | Soluble in Methyl acetate (supplied pre-dissolved - 1mg/ml) | | form | methyl acetate solution |
| | 15D-PGJ2 Usage And Synthesis |
| Uses | 15-Deoxy-Δ12,14-prostaglandin J2 has been used:
- to study its effect on lipid accumulation, viability/mitochondrial activity, and amount of vasculature in vascularized adipose tissue model
- as a peroxisome proliferator-activated receptor (PPARγ) agonist to activate intestinal fatty acid binding protein (I-FABP)-PPARγ pathway
- as a supplement in culture medium for induced neural stem/progenitor cells (NSPCs) differentiation
| | Definition | ChEBI: 15-deoxy-Delta(12,14)-prostaglandin J2 is a prostaglandin J derivative comprising prostaglandin J2 lacking the 15-hydroxy group and having C=C double bonds at the 12- and 14-positions. It has a role as a metabolite, an electrophilic reagent and an insulin-sensitizing drug. It is functionally related to a prostaglandin J2. It is a conjugate acid of a 15-deoxy-Delta(12,14)-prostaglandin J2(1-). | | General Description | A metabolite of PGD2 that has recently been identified as a natural ligand for PPARγ-dependent adipogenesis in transfected 3T3 cells and for PPARγ response element (PPRE) in CV-1 cells. Competes with thiazolidinediones for PPARγ binding. | | Biological Activity | Selective PPAR γ agonist that induces adipocyte differentiation in C3H10Y1/2 fibroblasts (EC 50 = 7 μ M). | | Biochem/physiol Actions | 15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) regulates inflammatory response in vivo. 15d-PGJ2 also elicits PPARγ-independent inhibition of nuclear factor (NF)-κB dependent transcription. It acts as an anti-angiogenic factor and triggers endothelial cell apoptosis. |
| | 15D-PGJ2 Preparation Products And Raw materials |
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