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JTE-013

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Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:JTE-013
CAS:383150-41-2
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: BOC Sciences
Tel: +1-631-485-4226
Email: inquiry@bocsci.com
Products Intro: Product Name:JTE-013
CAS:383150-41-2
Purity:>98% Package:25mg Remarks:BOC Sciences also provides custom synthesis services for JTE-013.
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:JTE-013
CAS:383150-41-2
Purity:98.00% Package:1 mL * 10mM (in DMSO)；10 mg；25 mg；5 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Alfa Chemistry
Tel: +1-5166625404
Email: Info@alfa-chemistry.com
Products Intro: Product Name:Jte 013
CAS:383150-41-2
Purity:>=98% Remarks:https://www.alfa-chemistry.com/cas_383150-41-2.htm
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:JTE-013
CAS:383150-41-2
Purity:98% Package:5mg Remarks:V23005
JTE-013 Basic information
Product Name:JTE-013
Synonyms:1-[1,3-Dimethyl-4-(2-methylethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-4-(2,6-dichloro-4-pyridinyl)-semicarbazide;1-(2,6-dichloro-4-pyridyl)-3-[(4-isopropyl-1,3-dimethyl-pyrazolo[3,4-b]pyridin-6-yl)amino]urea;1-[1,3-Dimethyl-4-(2-methylethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-4-(3,5-dichloro-4-pyridinyl)-semicarbazide;CS-2553;N-(2,6-Dichloro-4-pyridinyl)-2-[1,3-dimethyl-4-(1-methylethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]hydrazinecarboxamide;JTE-013;JTE 013;JTE013;1-(2,6-dichloropyridin-4-yl)-3-[(1,3-dimethyl-4-propan-2-ylpyrazolo[3,4-b]pyridin-6-yl)amino]urea;Hydrazinecarboxamide, N-(2,6-dichloro-4-pyridinyl)-2-[1,3-dimethyl-4-(1-methylethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-
CAS:383150-41-2
MF:C17H19Cl2N7O
MW:408.29
EINECS:
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Mol File:383150-41-2.mol
JTE-013 Structure
JTE-013 Chemical Properties
density 1.50±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: ≥20mg/mL
pka9.32±0.43(Predicted)
form powder
color white to off-white
Safety Information
Hazard Codes T
Risk Statements 25
Safety Statements 45
RIDADR UN 2811 6.1 / PGIII
WGK Germany 3
MSDS Information
JTE-013 Usage And Synthesis
DescriptionSphingosine-1-phosphate (S1P) is a bioactive lipid that exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis. It exerts its activity by binding to five distinct G protein-coupled receptors, S1P1/EDG-1, S1P2/EDG-5, S1P3/EDG-3, S1P4/EDG-6, and S1P5/EDG-8. JTE-013 is a potent, selective sphingosine-1-phosphate 2 (S1P2) receptor antagonist that binds to the human and rat receptors with IC50 values of 17 and 22 nM, respectively, (IC50 values >10 μM for human S1P1 and S1P3). It reverses the inhibitory effects of S1P on cell migration of vascular endothelial cells and smooth muscle cells. Similarly, JTE-013 reverses the inhibition of S1P on invasion and migration of B16 melanoma cells. JTE-013 inhibits S1P-induced contraction of, as well as cyclic AMP accumulation in, coronary artery smooth muscle cells.
UsesJTE-013 has been used in in vitro blood?brain barrier (BBB) and blood?tumor barrier (BTB) assays.
DefinitionChEBI: 1-(2,6-dichloro-4-pyridinyl)-3-[(1,3-dimethyl-4-propan-2-yl-6-pyrazolo[3,4-b]pyridinyl)amino]urea is a pyrazolopyridine.
Biochem/physiol ActionsJTE-013 can enhance the excitability of small-diameter sensory neurons. It has the ability to repress sphingosine 1-phosphate (S1P)-mediated cellular migration.
storageStore at +4°C
JTE-013 Preparation Products And Raw materials
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