| Company Name: |
BOC Sciences |
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
OU749 manufacturers
- OU749
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- $81.00
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2026-08-29
- CAS:519170-13-9
- Purity: 99.70%
- Supply Ability: 10g
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| Product Name: | OU749 | | Synonyms: | N-[5-(4-Methoxybenzyl)-1,3,4-thiadiazol-2-yl]benzenesulfonamide;OU749;Benzenesulfonamide, N-[5-[(4-methoxyphenyl)methyl]-1,3,4-thiadiazol-2-yl]-;N-[5-[(4-methoxyphenyl)methyl]-1,3,4-thiadiazol-2-yl]-benzenesulfonamide;OU749, 10 mM in DMSO | | CAS: | 519170-13-9 | | MF: | C16H15N3O3S2 | | MW: | 361.44 | | EINECS: | | | Product Categories: | | | Mol File: | 519170-13-9.mol |  |
| | OU749 Chemical Properties |
| storage temp. | 2-8°C | | solubility | DMSO: >20mg/mL | | form | solid | | color | white to off-white |
| Hazard Codes | Xn | | Risk Statements | 22 |
| | OU749 Usage And Synthesis |
| Uses | OU749 is a potent γ-glutamyl transpeptidase (GGT) inhibitor with a Ki value of 17.6 μM. OU749 shows cytotoxicity[1]. | | Biological Activity | ou749 is a competitive inhibitor of γ-glutamyl transpeptidase (ggt) [1].expression of γ-glutamyl transpeptidase (ggt) in tumors contributes to the resistance to radiation and chemotherapy. ggt is inhibited by glutamine analogues which compete with the substrate for the γ-glutamyl binding site [1].ou749 inhibited human kidney ggt with an intrinsic ki of 17.6 m [1]. in 786-o cells, a human renal tumor cell line, ou749 showed more than 150-fold less toxic than the ggt inhibitor acivicin toward dividing cells. ou749 inhibited ggt isolated from human kidney in a dose-dependent manner [1]. ou749 was 7-fold less potent as inhibitor of ggt isolated from rat kidney and 10-fold less potent inhibiting ggt from mouse kidney [1]. ou749 did not inhibit degradation of glutathione by ggt from rat kidney. inhibition of ggt by ou749 is species-specific [1]. ou749 showed no inhibitory effect on ggt from pig cells. ou749 inhibited human ggt expressed in mouse fibroblasts by a similar extent to the ggt from human cells, indicated that the species specificity was determined by differences in the primary structure of the protein rather than species-specific, post-translational modifications [1]. | | references | [1] king j b, west m b, cook p f, et al. a novel, species-specific class of uncompetitive inhibitors of γ-glutamyl transpeptidase[j]. journal of biological chemistry, 2009, 284(14): 9059-9065. |
| | OU749 Preparation Products And Raw materials |
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