8]naphthyridin-6(5H)-one

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Company Name: TargetMol Chemicals Inc.  
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Company Name: Blocksynth Pharmaceutical Technology Co.,Ltd  
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Company Name: Shanghai Yifei Biotechnology Co. , Ltd.  
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Company Name: Ningbo Zhenyue Pharmaceutical Technology Co., Ltd  
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8]naphthyridin-6(5H)-one manufacturers

  • XU1
  • XU1 pictures
  • $197.00
  • 2026-07-27
  • CAS:53439-81-9
  • Purity: 99.72%
  • Supply Ability: 10g
8]naphthyridin-6(5H)-one Basic information
Product Name:8]naphthyridin-6(5H)-one
Synonyms:8]naphthyridin-6(5H)-one;benzo[c][1;benzo[c][1,8]naphthyridin-6(5h)-one;XU1;XU1,XU-1
CAS:53439-81-9
MF:C12H8N2O
MW:196.2
EINECS:
Product Categories:
Mol File:53439-81-9.mol
8]naphthyridin-6(5H)-one Structure
8]naphthyridin-6(5H)-one Chemical Properties
Safety Information
MSDS Information
8]naphthyridin-6(5H)-one Usage And Synthesis
DescriptionXU1 is a potent and selective pan Aurora inhibitor; Phosphorylation of histone H3 (pHH3) inhibitor.
UsesBenzo[c][1,8]naphthyridin-6(5H)-one exhibits low micromolar affinity to human adenosine receptor (AR) A1 and hA2A, with Ki of 4.6 and 4.8 μM. Benzo[c][1,8]naphthyridin-6(5H)-one is inhibitor for poly ADP-ribose polymerase-1 (PARP-1) and aurora kinase A, with IC50 of 0.311 and 5.5 μM[1][2][3].
IC 50PARP-1: 0.311 μM (IC50); Aurora A: 5.5 μM (IC50); hA1AR: 4.6 μM (Ki); hA2AAR: 4.8 μM (Ki)
References[1] van der Horst E, et al., Multi-objective evolutionary design of adenosine receptor ligands. J Chem Inf Model. 2012 Jul 23;52(7):1713-21. DOI:10.1021/ci2005115
[2] Ferraris D, et al., Design and synthesis of poly ADP-ribose polymerase-1 inhibitors. 2. Biological evaluation of aza-5[H]-phenanthridin-6-ones as potent, aqueous-soluble compounds for the treatment of ischemic injuries. J Med Chem. 2003 Jul 3;46(14):3138-51. DOI:10.1021/jm030109s
[3] Karra S, et al., SAR and evaluation of novel 5H-benzo[c][1,8]naphthyridin-6-one analogs as Aurora kinase inhibitors. Bioorg Med Chem Lett. 2013 May 15;23(10):3081-7. DOI:10.1016/j.bmcl.2013.03.008
8]naphthyridin-6(5H)-one Preparation Products And Raw materials
Tag:8]naphthyridin-6(5H)-one(53439-81-9) Related Product Information
2-Amino-N-(3-methyl-2-pyridyl)benzamide 8]naphthyridin-6(5H)-one 1-Chlorobenzo[c][1,8]naphthyridin-6(5H)-one NA 4-Methyl-N-(5-Methyl-2-pyridinyl)benzaMide 5-Amino-2-methyl-N-(4-methylpyridin-2-yl)benzamide