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| 化学名: | 鉱油ミスト | | 英語化学名: | Paraffin, liquid | | 别名: | PARAFFIN VISCID, EXTRA PURE, DAB, PH. EU R., B. P., PH. FRANC.;VASELINE OIL EXTRA PURE COSMETIC GRADE;VASELINE OIL COLOURLESS FOOD GRADE;ParafinLiquidColourless,Heavy;ParaffinLiquidForIrSpectroscopy;ParafinLiquidColourless,Light;Mineraloil~Paraffinoil;Paraffin, liquid, pure | | CAS番号: | 8012-95-1 | | 分子式: | unspecified | | 分子量: | 0 | | EINECS: | 232-384-2 | | カテゴリ情報: | Analytical Reagents;Analytical/Chromatography;Infrared (IR) Spectroscopy;IR Solvents;IR Spectroscopy Solvents;NMR;Solvent by Application;Solvents;Spectroscopy Solvents (IR;UV/Vis);Lipids and Related ProductsPharmacopoeia (USP);Pharmacopoeia A-Z;Core Bioreagents;Research Essentials;IR Spectroscopy;IR Spectroscopy Solvents;Spectroscopy | | Mol File: | Mol File | ![鉱油ミスト]() |
| 融点 | -24 °C (lit.) | | 沸点 | 300 °C (lit.) | | 比重(密度) | 0.827-0.890 g/mL at 20 °C | | 屈折率 | n20/D 1.467(lit.) | | 闪点 | >300°C | | 貯蔵温度 | Store at room temperature. | | 溶解性 | Practically insoluble in ethanol (95%), glycerin, and
water; soluble in acetone, benzene, chloroform, carbon disulfide,
ether, and petroleum ether. Miscible with volatile oils and fixed
oils, with the exception of castor oil. | | 外見 | light oil | | 色 | white | | 比重 | 0.870 (20/4℃) | | 臭い (Odor) | Odorless | | 水溶解度 | Soluble in ether. Sparingly soluble in ethanol. Not miscible or difficult to mix in water. | | Merck | 14,7023 | | 暴露限界値 | ACGIH: TWA 5 mg/m3
OSHA: TWA 5 mg/m3
NIOSH: IDLH 2500 mg/m3; TWA 5 mg/m3; STEL 10 mg/m3 | | Dielectric constant | 2.0（Ambient） | | EPAの化学物質情報 | Paraffin oils (8012-95-1) |
| | 鉱油ミスト Usage And Synthesis |
| 定義 | 本品は、石油から得られる常温で液体の炭化水素の混合物である。 | | 化粧品の成分用途 | エモリエント剤、ヘアコンディショニング剤、閉塞剤、皮膚保護剤、溶剤、香料 | | 説明 | Mineral oil mist is a colorless, oily liquid aero-sol dispersed in air with an odor like burned lubricating oil.The odor threshold is 1.0 ppm. Specific gravity (H2O:1)=0.865 at 60℃; Boiling point = 250- 360*C; Vaporpressure = <0.5 mmHg at 20℃; Flash point= 193℃;Autoignition temperature = 260- 371℃. HazardIdentification (based on NFPA-704 M Rating System):Health 0, Flammability 1, Reactivity 0. Insoluble in water. | | 化学的特性 | Mineral oil is a transparent, colorless, viscous oily liquid, without
fluorescence in daylight. It is practically tasteless and odorless when
cold, and has a faint odor of petroleum when heated. | | 化学的特性 | Clear colorless oil | | 使用 | Mineral oil is a lubricant and is used as
a solvent for inks in the printing industry. | | 使用 | Laxative; pharmaceutic aid (solvent). | | 使用 | Paraffin Oils is a useful organic solvent for isolating the nucleus of the gian amphibian oocyte. | | 調製方法 | Mineral oil is obtained by distillation of petroleum. The lighter
hydrocarbons are first removed by distillation and the residue is
then redistilled between 330–390°C. The distillate is chilled and the
solid fractions are removed by filtration. The filtrate is then further
purified and decolorized by high-pressure hydrogenation or sulfuric
acid treatment; the purified filtrate is then filtered through
adsorbents. The liquid portion obtained is distilled and the portion
boiling below 360°C is discarded. A suitable stabilizer may be
added to the mineral oil; | | 定義 | Liquid hydrocarbons from petroleum. | | brand name | Balneol
(Solvay Pharmaceuticals); Neo-Cultol (Fisons); Nujol
(Schering-Plough HealthCare). | | 一般的な説明 | Transparent colorless oily liquid. Practically tasteless and odorless, even when warmed. | | 空気と水の反応 | Flammable. Insoluble in water. | | 反応プロフィール | OIL. [MINERAL] may be incompatible with strong oxidizing agents like nitric acid. Charring may occur followed by ignition of unreacted oil and other nearby combustibles. In other settings, mostly unreactive. Not affected by aqueous solutions of acids, alkalis, most oxidizing agents, and most reducing agents. Burns exothermically when heated sufficiently or when ignited in the presence of air, oxygen or strong oxidizing agents. | | 危険性 | Inhalation of vapor or particulates can causeaspiration pneumonia. Combustible liquid. Upperrespiratory tract irritant. Questionable carcinogen. | | 健康ハザード | Highly refined mineral oil mist
is of low toxicity. | | 火災危険 | PARAFFIN is combustible. | | 応用例（製薬） | Mineral oil is used primarily as an excipient in topical pharmaceutical
formulations, where its emollient properties are exploited as an
ingredient in ointment bases. It is additionally used in
oil-in-water emulsions,as a solvent, and as a lubricant in
capsule and tablet formulations, and to a limited extent as a mold-release agent for cocoa butter suppositories. It has also been used in
the preparation of microspheres and as a vaccine adjunct.
Therapeutically, mineral oil has been used as a laxative.It is indigestible and thus has limited absorption.
Mineral oil is used in ophthalmic formulations for its lubricant
properties. It is also used in cosmetics and some food products. | | 安全性プロファイル | A human teratogen by
inhalation that causes testicular tumors in
the fetus. Inhalation of vapor or particulates
can cause aspiration pneumonia. A skin and
eye irritant. Highly purified food grades are
of low toxicity. Questionable human
carcinogen producing gastrointestinal
tumors. Slightly combustible liquid when
exposed to heat or flame. To fight fire, use
dry chemical, CO2, foam. When heated to
decomposition it emits acrid smoke and
fumes. | | 安全性 | Mineral oil is used as an excipient in a wide variety of
pharmaceutical formulations. It is also used in
cosmetics and in some food products.
Therapeutically, mineral oil has been used in the treatment of
constipation, as it acts as a lubricant and stool softener when taken
orally. Daily doses of up to 45mL have been administered orally,
while doses of up to 120mL have been used as an enema. However,
excessive dosage of mineral oil, either orally or rectally, can result in
anal seepage and irritation, and its oral use as a laxative is not
considered desirable.
Chronic oral consumption of mineral oil may impair the appetite
and interfere with the absorption of fat-soluble vitamins. Prolonged
use should be avoided. Mineral oil is absorbed to some extent when
emulsified and can lead to granulomatous reactions. Similar
reactions also occur upon injection of the oil;injection may
also cause vasospasm.
The most serious adverse reaction to mineral oil is lipoid
pneumonia caused by aspiration of the oil.Mineral oil can
enter the bronchial tree without eliciting the cough reflex.With
the reduction in the use of mineral oil in nasal formulations, the
incidence of lipoid pneumonia has been greatly reduced. However,
lipoid pneumonia has also been associated with the use of mineral
oil-containing cosmetics and ophthalmic preparations.It is
recommended that products containing mineral oil not be used in
very young children, the elderly, or persons with debilitating
illnesses.
Given its widespread use in many topical products, mineral oil
has been associated with few instances of allergic reactions.
The WHO has not specified an acceptable daily intake of
mineral oil given the low concentration consumed in foods.
LD50 (mouse, oral): 22 g/kg | | 職業ばく露 | Tumorigen,Human Data; Primary Irritant. Mineral oil is used in cosmetics, pharmaceutical bases, food, and fiber production; ascarriers and bases; as a lubricating oil; and as a solvent forinks in the printing industry. Oil mist would be encounteredin quenching of hot metal parts and in metal machiningoperations. | | 応急処置 | If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility | | 貯蔵 | Mineral oil undergoes oxidation when exposed to heat and light.
Oxidation begins with the formation of peroxides, exhibiting an
‘induction period’. Under ordinary conditions, the induction period
may take months or years. However, once a trace of peroxide is
formed, further oxidation is autocatalytic and proceeds very
rapidly. Oxidation results in the formation of aldehydes and
organic acids, which impart taste and odor. Stabilizers may be added to retard oxidation; butylated hydroxyanisole, butylated
hydroxytoluene, and alpha tocopherol are the most commonly used
antioxidants.
Mineral oil may be sterilized by dry heat.
Mineral oil should be stored in an airtight container, protected
from light, in a cool, dry place. | | 純化方法 | Treat the oil with fuming H2SO4 (care), then wash it with water and dilute aqueous NaOH, then percolate it through activated silica gel. Paraffin Wax. Melt the wax in the presence of NaOH, wash it with water until all of the base had been removed. The paraffin is allowed to solidify after each wash. Finally, 5g of paraffin is melted by heating it on a water-bath, then shaken for 20-30minutes with 100mL of boiling water and and dry the melt under vacuum. | | 不和合性 | Incompatible with strong oxidizing agents. | | 規制状況(Regulatory Status) | GRAS listed. Accepted in the UK for use in certain food
applications. Included in the FDA Inactive Ingredients Database
(dental preparations; IV injections; ophthalmic preparations; oral
capsules and tablets; otic, topical, transdermal, and vaginal
preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal
Ingredients. |
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