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4-[[3,4-(METHYLENEDIOXY)BENZYL]AMINO]-6-CHLOROQUINAZOLINE

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4-[[3,4-(METHYLENEDIOXY)BENZYL]AMINO]-6-CHLOROQUINAZOLINE Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:MBCQ
CAS:150450-53-6
Package:10 mg；100 mg；2 mg；200 mg；25 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:v2330
CAS:150450-53-6
Purity:98% Package:10mg Remarks:V2330
Company Name: Aladdin Scientific
Tel: +1-833-552-7181
Email: sales@aladdinsci.com
Products Intro: Product Name:MBCQ
CAS:150450-53-6
Purity:98% Package:$83.9/5mg;$147.9/10mg;$296.9/25mg;$494.9/50mg;$891.9/100mg;$2004.9/250mg;Bulk pa Remarks:98%
Company Name: Shanghai EFE Biological Technology Co., Ltd.  
Tel: 021-65675885 18964387627
Email: info@efebio.com
Products Intro: Product Name:MBCQ
CAS:150450-53-6
Purity:99% Package:1mg;5mg;10mg
Company Name: Tianjin Kailiqi Biotechnology Co., Ltd.  
Tel: 15076683720
Email: klq@cw-bio.com
Products Intro: Product Name:MBCQ
CAS:150450-53-6
Purity:>98% Package:100mg 1g,5g,根据客户需要分装 Remarks:2g
4-[[3,4-(METHYLENEDIOXY)BENZYL]AMINO]-6-CHLOROQUINAZOLINE Basic information
Product Name:4-[[3,4-(METHYLENEDIOXY)BENZYL]AMINO]-6-CHLOROQUINAZOLINE
Synonyms:MBCQ;4-[[3,4-(METHYLENEDIOXY)BENZYL]AMINO]-6-CHLOROQUINAZOLINE;N-(1,3-BENZODIOXOL-5-YLMETHYL)-6-CHLORO-4-QUINAZOLINAMINE;4-Quinazolinamine, N-(1,3-benzodioxol-5-ylmethyl)-6-chloro-;v2330;cGMP-PDE,inhibit,arteries,PGF2α,Inhibitor,MBCQ,Phosphodiesterase (PDE),coronary;N-(Benzo[d][1,3]dioxol-5-ylmethyl)-6-chloroquinazolin-4-amine
CAS:150450-53-6
MF:C16H12ClN3O2
MW:313.74
EINECS:
Product Categories:
Mol File:150450-53-6.mol
4-[[3,4-(METHYLENEDIOXY)BENZYL]AMINO]-6-CHLOROQUINAZOLINE Structure
4-[[3,4-(METHYLENEDIOXY)BENZYL]AMINO]-6-CHLOROQUINAZOLINE Chemical Properties
storage temp. 2-8°C
solubility DMSO: soluble5mg/mL (clear solution)
form powder
color white to beige
Safety Information
WGK Germany 3
MSDS Information
4-[[3,4-(METHYLENEDIOXY)BENZYL]AMINO]-6-CHLOROQUINAZOLINE Usage And Synthesis
UsesMBCQ is a selective inhibitor of cGMP-specific phosphodiesterase.
DefinitionChEBI: N-(1,3-benzodioxol-5-ylmethyl)-6-chloro-4-quinazolinamine is a member of quinazolines.
Biological Activitymbcq is a cgmp-specific phosphodiesterase pde5 inhibitor.the phosphodiesterase type 5 inhibitor (pde5 inhibitor) is an agent used to inhibit the degradative action of cgmp-specific pde5 on cyclic gmp in the smooth muscle cells lining the blood vessels supplying the corpus cavernosum of the penis. pde5 drugs are used in the treatment of erectile dysfunction and were the first effective oral treatment for this condition. sinve pde5 is also present in the arterial wall smooth muscle within the lungs, pde5 inhibitors have also been applied for the pulmonary hypertension treatment.
in vitroin previous study, it was found that the addition of mbcq to the blood vessle samples could lead to an 80 to 85% inhibition of pde activity, indicating that most of the activity present in these blood vessels could be attributed to pde5. [1].
in vivoin animal rat study, tolerance was induced by continuous exposure to glyceryl trinitrate (gtn) for 48 h. results showed that mbcq could significantly decrease the ec(50) values for gtn-induced relaxation in both tolerant and nontolerant tissues, but with the greatest relative shift showing in tolerant veins. moreover, mbcq could also increase the vasodilator potency of a nitric oxide donor (1,1-diethyl-2-hydroxy-2-nitrosohydrazine). a significant increase in cgmp pde activity was found in tolerant femoral vein, whereas pde activity was unchanged in femoral artery [1].
references[1] macpherson jd, gillespie td, dunkerley ha, maurice dh, bennett bm. inhibition of phosphodiesterase 5 selectively reverses nitrate tolerance in the venous circulation. j pharmacol exp ther. 2006 apr;317(1):188-95.
4-[[3,4-(METHYLENEDIOXY)BENZYL]AMINO]-6-CHLOROQUINAZOLINE Preparation Products And Raw materials
Tag:4-[[3,4-(METHYLENEDIOXY)BENZYL]AMINO]-6-CHLOROQUINAZOLINE(150450-53-6) Related Product Information
ZARDAVERINE RO 20-1724 AG 1295 S- (+)-Rolipram ETAZOLATE BRL 50481 Vinpocetine ZAPRINAST ROLIPRAM Cilostazol (4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE CILOSTAMIDE EHNA HYDROCHLORIDE N-Benzylquinazoline-4-amine N-(1,3-BENZODIOXOL-5-YLMETHYL)-4-QUINAZOLINAMINE (4-METHOXYBENZYL)(QUINAZOLIN-4-YL)AMINE 4-[[3,4-(METHYLENEDIOXY)BENZYL]AMINO]-6-CHLOROQUINAZOLINE 6-CHLOROQUINAZOLIN-4-AMINE