|
|
| Product Name: | GSA 10 | | Synonyms: | Propyl 4-(1-hexyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)benzoate;GSA 10;propyl 4-[(1-hexyl-4-hydroxy-2-oxo-quinoline-3-carbonyl)amino]benzoate;4-[[(1-Hexyl-1,2-dihydro-2-oxo-3-quinolinyl)carbonyl]amino]benzoic acid propyl ester;Inhibitor,differentiation,regenerative medicine,Smoothened receptor,quinolinecarboxamide derivative,cancer,Smoothened,GSA 10,GSA-10,Smo,osteoblasts,Hedgehog,GSA10,inhibit,multipotent mesenchymal progenitor cell;Benzoic acid, 4-[[(1-hexyl-1,2-dihydro-4-hydroxy-2-oxo-3-quinolinyl)carbonyl]amino]-, propyl ester | | CAS: | 300833-95-8 | | MF: | C26H30N2O5 | | MW: | 450.53 | | EINECS: | | | Product Categories: | | | Mol File: | 300833-95-8.mol |  |
| | GSA 10 Chemical Properties |
| Boiling point | 620.2±55.0 °C(Predicted) | | density | 1.240±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble to 5 mM in DMSO with gentle warming | | form | Powder | | pka | 4.50±1.00(Predicted) |
| | GSA 10 Usage And Synthesis |
| Description | Smoothened (SMO) is a cell surface receptor that, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors. GSA 10 is a quinolinecarboxamide derivative that acts as an agonist of SMO. By acting at SMO, GSA 10 has been shown to promote the differentiation of multipotent mesenchymal progenitor cells into osteoblasts (EC50 = 1.2 μM). Most notably, GSA 10 does not recognize the classic cyclopamine binding site as do other SMO agonists and as such has been used to characterize a novel SMO active site. | | Uses | GSA 10 is a novel small-molecule positive modulator of smoothened. GSA 10 may have therapeutic interests in regenerative medicine. |
| | GSA 10 Preparation Products And Raw materials |
|