化合物SUN 11602
中文名称 | 化合物SUN 11602 |
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中文同义词 | 化合物SUN 11602;SUN 11602,碱性成纤维细胞生长因子(BFGF)类似物 |
英文名称 | SUN11602 |
英文同义词 | SUN11602;4-[[4-[[2-[(4-Amino-2,3,5,6-tetramethylphenyl)amino]acetyl]methylamino]-1-piperidinyl]methyl]benzamide;CS-2504;SUN11602;SUN11602;inhibit,Fibroblast growth factor receptor,SUN11602,FGFR,Inhibitor,SUN-11602;Benzamide, 4-[[4-[[2-[(4-amino-2,3,5,6-tetramethylphenyl)amino]acetyl]methylamino]-1-piperidinyl]methyl]- |
CAS号 | 704869-38-5 |
分子式 | C26H37N5O2 |
分子量 | 451.60428 |
EINECS号 | |
相关类别 | |
Mol文件 | 704869-38-5.mol |
结构式 |
化合物SUN 11602 性质
沸点 | 679.8±55.0 °C(Predicted) |
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密度 | 1.19±0.1 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | 可溶于DMSO |
形态 | 结晶固体 |
酸度系数(pKa) | 16.19±0.50(Predicted) |
颜色 | 浅黄至黄色 |
SUN11602 prevents glutamate-induced neuronal death in primary cultures of rat cerebrocortical neurons. SUN11602 increases the levels of CALB1 gene expression in cerebrocortical neurons. SUN11602 exerts protective effects on hippocampal neurons through activation of FGFR1 and increases CalB expression. SUN11602 promotes neurite outgrowth of primarily cultured rat hippocampal neurons.
In WT mice, SUN11602 increases the levels of newly synthesized Calb in cerebrocortical neurons and suppresses the glutamate-induced rise in intracellular Ca 2+ . This Ca 2+ -capturing ability of Calb allows the neurons to survive severe toxic conditions of glutamate. Oral administration of SUN11602 at the midpoint of Aβ1-40 and ibotenate injections attenuate short-term memory impairment in the Y-maze test, as well as spatial learning deficits in the water maze task. In addition, the SUN11602 treatment inhibits the increase of peripheral-type benzodiazepine-binding sites (PTBBS),which are a marker for gliosis.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-101493 | SUN11602 | 704869-38-5 | 5mg | 700元 |
2024/08/19 | HY-101493 | SUN11602 | 704869-38-5 | 10mM * 1mLin DMSO | 770元 |