无中文名称
| 中文名称 | 无中文名称 |
|---|---|
| 中文同义词 | PRMT5抑制剂(HLCL-61 HYDROCHLORIDE);HLCL-61 盐酸盐;化合物HLCL-61 HYDROCHLORIDE;1-(9-乙基-9H-咔唑-3-基)-N-(2-甲氧基苄基)甲胺盐酸盐 |
| 英文名称 | HLCL-61 (hydrochloride) |
| 英文同义词 | HLCL-61 (hydrochloride);HLCL-61.HCl;HLCL61;HLCL 61;CS-2798;HLCL61;HLCL 61;HLCL 61 HYDROCHLORIDE;1-(9-Ethyl-9H-carbazol-3-yl)-N-(2-methoxybenzyl)methanamine hydrochloride;Histone Methyltransferase,HLCL 61,HLCL-61,inhibit,HLCL 61 hydrochloride,Apoptosis,HLCL61 hydrochloride,Inhibitor |
| CAS号 | 1158279-20-9 |
| 分子式 | C23H25ClN2O |
| 分子量 | 380.92 |
| EINECS号 | |
| 相关类别 | 细胞生物学试剂;API |
| Mol文件 | 1158279-20-9.mol |
| 结构式 |  |
无中文名称 性质
| 储存条件 | Inert atmosphere,Store in freezer, under -20°C |
|---|---|
| 溶解度 | DMSO 中≥20.4 mg/mL；不溶于乙醇；不溶于水 |
| 形态 | 结晶固体 |
HLCL-61 hydrochloride 是首创的小分子蛋白精氨酸甲基转移酶 5 (PRMT5) 抑制剂。
Protein arginine methyltransferase 5
HLCL-61 hydrochloride (1-100 μM; 24-72 hours) reduces cells growth at dose-dependent manner with IC
50
s of 14.12, 16.74, 6.3, 8.72 μM for MV4-11 cells, THP-1 cells, FLT3-WT blast, and FLT3-ITD blast, respectively.
HLCL-61 hydrochloride shows effective inhibition of symmetric arginine dimethylation (me2) of histones H3 and H4 in AML samples, starting at 12 h post-treatment and persisting after 48 h.
Cell Viability Assay
| Cell Line: | MV4-11 cells, THP-1 cells, FLT3-WT blast (primary blasts from patients), FLT3-ITD blast (primary blasts from patients) |
| Concentration: | 1, 5, 10, 25, 50, 100 μM |
| Incubation Time: | 24, 48, 72 hours |
| Result: | Dose-dependent reduction in cell viability with IC 50 s of 14.12, 16.74, 6.3, 8.72 μM for MV4-11 cells, THP-1 cells, FLT3-WT blast, and FLT3-ITD blast, respectively. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-100025A | 1-(9-乙基-9H-咔唑-3-基)-N-(2-甲氧基苄基)甲胺盐酸盐 HLCL-61 hydrochloride | 1158279-20-9 | 5mg | 500元 |
| 2024/01/25 | HY-100025A | 1-(9-乙基-9H-咔唑-3-基)-N-(2-甲氧基苄基)甲胺盐酸盐 HLCL-61 hydrochloride | 1158279-20-9 | 10mM * 1mLin DMSO | 550元 |