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| | 6-ForMylindolo[3,2-b]carbazole Basic information |
| Product Name: | 6-ForMylindolo[3,2-b]carbazole | | Synonyms: | 6-FORMYLINDOLO [3,2-B] CARBAZOLE;Indolo[3,2-b]carbazole-6-carbaldehyde;5,11-dihydroindolo[3,2-b]carbazole-6-carbaldehyde;5H,11H-indolo[3,2-b]carbazole-6-carbaldehyde;5,11-Dihydroindolo[3,2-b]carbazole-6-carboxaldehyde;6-FORMYLINDOLO A CARBAZOLE;Indolo[3,2-b]carbazole-6-carboxaldehyde, 5,11-dihydro-;6-Formylindolo[3,2-b]carbazole (FICZ) | | CAS: | 172922-91-7 | | MF: | C19H12N2O | | MW: | 284.31 | | EINECS: | | | Product Categories: | | | Mol File: | 172922-91-7.mol | ![6-ForMylindolo[3,2-b]carbazole Structure](CAS/GIF/172922-91-7.gif) |
| | 6-ForMylindolo[3,2-b]carbazole Chemical Properties |
| Boiling point | 630.3±35.0 °C(Predicted) | | density | 1.463±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | Soluble in DMSO (up to 10 mg/ml). | | pka | 15.66±0.30(Predicted) | | form | powder | | color | yellow to orange | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. |
| | 6-ForMylindolo[3,2-b]carbazole Usage And Synthesis |
| Description | 6-Formylindolo(3,2-b)carbazole (FICZ) (172922-91-7) is a very potent (Kd?= 0.07 nM) endogenous ligand for the aryl hydrocarbon receptor (AhR).1,2 | | Uses | 6-Formylindolo[3,2-b]carbazole is a tryptophan photoproduct, suppresses pulmonary eosinophilia and Th2-type cytokine production in a mouse model of ovalbumin-induced allergic asthma. | | Biochem/physiol Actions | FICZ is a potent high affinity ligand of the aryl hydrocarbon receptor (AhR), which is a ligand-activated transcription factor that activates the expression of aromatic hydrocarbon metabolizing enzyme genes such as the CYP1A1 gene and has also been shown to have multiple additional roles in cell-cycle regulation, development and maturation of many tissues, control of inflammation, and immune response. FICZ is a photoproduct of tryptophan and is believed to be an endogenous AhR ligand. It is extremely potent, with a Kd value of 0.07 nM. | | storage | Store at -20°C | | References | 1) Rannung?et al. (1987)?Certain photooxidized derivatives of tryptophan bind with very high affinity to the Ah receptor and are likely to be endogenous signal substances; J. Biol. Chem.,?262?15422
.2) Wincent?et al. (2009)?The Suggested Physiologic Aryl Hydrocarbon Receptor Activator and Cytochrome P4501 Substrate 6-Formylindolo[3,2-b}carbazole is Present in Humans; J. Biol. Chem.,?284?2690 |
| | 6-ForMylindolo[3,2-b]carbazole Preparation Products And Raw materials |
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