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| | LY3214996 Basic information |
| Product Name: | LY3214996 | | Synonyms: | LY3214996;6,6-dimethyl-2-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)-5-(2-morpholinoethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrol-4-one;CS-2495;4H-Thieno[2,3-c]pyrrol-4-one, 5,6-dihydro-6,6-dimethyl-2-[2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]-5-[2-(4-morpholinyl)ethyl]-;Temuterkib;Temuterkib (LY3214996);LY-3214996,LY 3214996,inhibit,Extracellular signal regulated kinases,Temuterkib,Inhibitor,ERK;LY-3214996 (LY3214996) | | CAS: | 1951483-29-6 | | MF: | C22H27N7O2S | | MW: | 453.56 | | EINECS: | | | Product Categories: | | | Mol File: | 1951483-29-6.mol |  |
| | LY3214996 Chemical Properties |
| Boiling point | 711.5±70.0 °C(Predicted) | | density | 1.43±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO:23.5(Max Conc. mg/mL);51.81(Max Conc. mM)
Ethanol:16.0(Max Conc. mg/mL);35.28(Max Conc. mM) | | form | A crystalline solid | | pka | 6.58±0.10(Predicted) |
| | LY3214996 Usage And Synthesis |
| Description | LY3214996 is an inhibitor of ERK1 and ERK2 (IC50 = 5 nM for both). It inhibits cell proliferation of tumor cells in vitro, including those expressing B-RAF, N-Ras, or K-Ras mutations. LY3214996 inhibits tumor growth in B-RAF or N-Ras mutant melanoma, B-RAF or K-Ras mutant colorectal, lung, and pancreatic cancer mouse xenograft models, as well as patient-derived xenograft (PDX) mouse models. |
| | LY3214996 Preparation Products And Raw materials |
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