171722-81-9
| 中文名称 | 171722-81-9 |
|---|---|
| 中文同义词 | 化合物 T13370 |
| 英文名称 | YM-46303 |
| 英文同义词 | YM-46303;YM46303,YM 46303 |
| CAS号 | 171722-81-9 |
| 分子式 | C20H23ClN2O2 |
| 分子量 | 358.87 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 171722-81-9.mol |
| 结构式 |  |
171722-81-9 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | 溶于二甲基亚砜 |
mAChR
YM-46303 shows approximately ten times higher inhibitory activity on bladder pressure in reflexly-evoked rhythmic contraction, and about 5-fold greater selectivity for urinary bladder contraction against salivary secretion in rats compared to oxybutynin. Further evaluation of antimuscarinic effects on bradycardia and pressor in pithed rats, and on tremor in mice, show that YM-46303 can be useful for the treatment of urinary urge incontinence as a bladder-selective M3 antagonist with potent activities and fewer side effects. YM-46303 shows in vivo selective inhibitory activities on bladder pressure in reflexly-evoked rhythmic contraction against oxotremorine-induced salivary secretion. In addition, YM-46303 has potent activity in a guinea pig model of methacholine-induced bronchospasm on intravenous administration.