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| 融点 | 106-110° (with decompn) | | 比重(密度) | 1.255-1.256 | | 貯蔵温度 | Refrigerator | | 溶解性 | Slightly soluble in water, sparingly soluble in ethanol (96 per cent). | | 色 | White to Off-White | | CAS データベース | 6130-64-9(CAS DataBase Reference) |
| 主な危険性 | Xn | | Rフレーズ | 42/43 | | Sフレーズ | 36 | | RTECS 番号 | XH9450000 | | HSコード | 2941102000 | | 毒性 | LD50 s.c. in mice: 2.3 g/kg (Soehring) |
| | プロカインペニシリンG水和物 Usage And Synthesis |
| 効能 | 抗生物質, 細胞壁合成阻害薬 | | 説明 | Benzylpenicillin procaine was developed as
a dilatorily acting benzylpenicillin, only slightly
soluble in water. It has been used with peanut oil
or carboxymethylcellulose as an oil suspension
or an aqueous suspension, respectively . | | 化学的特性 | White Solid | | 使用 | Procaine penicilline G hydrate is a composed of the β-lactam antibiotic of Penicillin G and the sodium channel blocker Procaine. As an antibiotic, Penicillin G is noted to posses effectiveness mainly against gram-positive organisms. Procaine Penicillin G is used a growth stimulant for poultry. | | 使用 | Procaine Penicillin G is a composed of the β-lactam antibiotic of Penicillin G and the sodium channel blocker Procaine. As an antibiotic, Penicillin G is noted to posses effectiveness mainly against gram-positive organisms. Procaine Penicillin G is used a growth stimulant for poultry. | | brand name | Duracillin(Lilly); Pfizerpen (Pfizer). | | 抗菌性 | The procaine salt of benzylpenicillin. Poorly soluble (1:200 in
water). Administered intramuscularly as a suspension of crystals
which slowly dissolve at the site of the injection.
It must not be given intravenously. Intramuscular administration
produces a flat sustained plasma concentration of
penicillin, which is much lower than that achieved by an
equivalent dose of benzylpenicillin, with plasma levels still
detectable 24 h later. An injection of 0.6 g yields a peak plasma
concentration of 1–2 mg benzylpenicillin/L after 2–4 h. Free
procaine is detectable in the plasma within 30 min.
Very severe and potentially fatal reactions resembling those
of anaphylactic shock, but non-allergic in character, may
occur, probably due to accidental entry into the vascular system
at the site of injection and blockage of pulmonary and
cerebral capillaries by crystals of the suspension. Reactions
due to liberated procaine may include acute anxiety, hypertension,
tachycardia, vomiting, audiovisual hallucinations and
acute psychotic disturbance. The most severe reactions lead
to convulsions and cardiac arrest. Other reactions are those to
liberated benzylpenicillin. |
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