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ChemicalBook Optimization Suppliers |
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| | テトラデシルトリメチルアンモニウムブロミド 製品概要 |
| | テトラデシルトリメチルアンモニウムブロミド 物理性質 |
| 融点 | 245-250 °C(lit.) | | 比重(密度) | 1.1328 (rough estimate) | | 蒸気圧 | 0Pa at 25℃ | | 屈折率 | 1.5260 (estimate) | | 貯蔵温度 | Store below +30°C. | | 溶解性 | H2O: 10 % (w/v) | | 外見 | Fine Crystalline Powder | | 色 | White | | PH | pH (50g/l, 25℃ : 4.0～6.0 | | 水溶解度 | 20 g/100 mL | | Sensitive | Hygroscopic | | 極大吸収波長 (λmax) | λ: 240 nm Amax: ≤0.08
λ: 250 nm Amax: ≤0.05
λ: 260 nm Amax: ≤0.04
λ: 500 nm Amax: ≤0.02 | | Merck | 14,6336 | | BRN | 3633227 | | 安定性： | Stable. Hygroscopic. Incompatible with strong oxidizing agents. | | InChIKey | CXRFDZFCGOPDTD-UHFFFAOYSA-M | | LogP | 2.2 at 20℃ | | CAS データベース | 1119-97-7(CAS DataBase Reference) | | EPAの化学物質情報 | Tetradecyl trimethyl ammonium bromide (1119-97-7) |
| 主な危険性 | C | | Rフレーズ | 34 | | Sフレーズ | 26-36/37/39-45-27 | | RIDADR | UN 3263 8/PG 2 | | WGK Germany | 3 | | RTECS 番号 | BS5776000 | | F | 3 | | TSCA | Yes | | 国連危険物分類 | 8 | | 容器等級 | II | | HSコード | 29239000 | | 毒性 | LD50 in mice, rats (mg/kg): 12.0, 15.0 i.v. (Issomaa, Bjondahl) |
| | テトラデシルトリメチルアンモニウムブロミド Usage And Synthesis |
| 外観 | 白色の粉末 | | 定義 | 本品は、次の化学式で表される4級アンモニウム塩である。 | | 溶解性 | 水に可溶。 100g/l (20℃)。水に溶けやすく、エタノールにやや溶けやすく、アセトンにほとんど溶けない。 | | 化粧品の成分用途 | 帯電防止剤、殺菌剤 | | 説明 | MiTMAB (1119-97-7) is a dynamin I/II inhibitor targeting the dynamin-phospholipid interaction and inhibiting dynamin GTPase activity with a Ki=940nM.1 Rapidly and reversibly inhibits multiple forms of endocytosis with no acute cellular damage1. A useful pharmacological tool for studying dynamin-mediated trafficking events.2 Induces cytokinesis failure and apoptosis in human cancer cells.3 Induces cytoprotective autophagy in human Jurkat T cells.4 | | 使用 | Myristyltrimethylammonium has been used in a study to assess a surfactant-controlled synthetic method to obtain a nanophase of mesoporous ceria-zirconia solid solution containing cationic defects in the crystalline structure.??It has also been used in a study to determine the low molecular weight of organic acids in soils and plants by capillary zone electrophoresis. | | 使用 | Disinfectant; deodorant; laboratory reagent. | | 定義 | Myristyltrimethylammonium bro-mide. | | 一般的な説明 | Myristyltrimethylammonium bromide is a cationic/zwitterionic type of surfactant. | | 純化方法 | Crystallise the bromide from acetone or a mixture of Me2CO and >5% MeOH or Me2CO/EtOH. Wash it with diethyl ether and dry it in a vacuum oven at 60o. It is a cationic detergent. Its solubility is 1g/5g H2O. [Dearden & Wooley J Phys Chem 91 2404 1987, Shelton et al. J Am Chem Soc 68 754 1946, Beilstein 4 III 419, 4 IV 813.] | | 参考文献 | 1) Quan et al. (2007), Myristal trimethyl ammonium bromide and octadecyl trimethyl ammonium bromide are surface-active small molecules dynamin inhibitors that block endocytosis mediated by dynamin I or dynamin II; Mol. Pharmacol., 72 1425
2) Joshi et al. (2011), Development and validation of a stability indicating method for the enantioselective estimation of omeprazole enantiomers in the enteric-coated formulations by high performance liquid chromatography; Mol. Cancer, 104 78
3) De Beco et al. (2009), Endocytosis is required for E-cadherin redistribution at mature adherens junctions; Proc. Natl. Acad. Sci. USA, 106 7010
4) Kim et al. (2016), Inhibition of autophagy enhances dynamin inhibitor-induced apoptosis via promoting Bak activation and mitochondrial damage in human Jurkat T cells; Biochem. Biophys. Res. Commun., 478 1609 |
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