Phe-Met-Arg-Phe amide
中文名称 | Phe-Met-Arg-Phe amide |
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中文同义词 | 心兴奋肽H-PHE-MET-ARG-PHE-NH2 |
英文名称 | Phe-Met-Arg-Phe amide trifluoroacetate |
英文同义词 | Phe-Met-Arg-Phe amide trifluoroacetate;Phe-Met-Arg-Phe amide trifluoroacetate,Phe-Met-Arg-Phe-NH2 trifluoroacetate,FMRF-NH2 trifluoroacetate?, >98%;PHE-MET-ARG-PHE AMIDE TRIFLUOROACETATE?, >98% |
CAS号 | 159237-99-7 |
分子式 | C31H43F3N8O6S |
分子量 | 712.79 |
EINECS号 | |
相关类别 | 目录多肽 |
Mol文件 | 159237-99-7.mol |
结构式 |
Phe-Met-Arg-Phe amide 性质
储存条件 | Store at -20°C |
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水溶解性 | Water : ≥ 50 mg/mL (60.47 mM) |
序列 | H-Phe-Met-Arg-Phe-NH2 |
ED50: 23 nM (K + current)
In the molluscan central nervous system, Phe-Met-Arg-Phe amide (FMRFa) acts on K + channels in sensory, motor-, and neuroendocrine neurones. Phe-Met-Arg-Phe amide activates a novel K + current that is characterized by a combined voltage- and receptor-dependent gating mechanism, with both factors being necessary for opening of the channels. Phe-Met-Arg-Phe amide (1 μM) significantly inhibits glucose stimulated (300 mg/dL) insulin release (p<0.005) and somatostatin release (p<0.01) from the isolated perfused pancreas. Phe-Met-Arg-Phe amide (FMRF-NH2) (1 and 10 μM) is without effect on glucagon secretion, either in low glucose (50 mg/dL), high glucose (300 mg/dL), or during arginine stimulation (5 mM).
Phe-Met-Arg-Phe amide (FMRFamide) stimulates growth hormone secretion in conscious OVX rats. The presence of Phe-Met-Arg-Phe amide-like immunoreactivity in neuronal elements in the hypothalamus suggested a role for this in the hypothalamic control of the anterior pituitary function. The injection of 200 ng (313.8 picomoles) of FMRFamide (in 2 uL) produces a significantly increased plasma GH 15 min after injection. The GH-increasing effect of 400-800 ng (627-1255 picomoles) of FMRFamide is already developed after 5 min and lasted up to 30 min.
纯度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
内毒素≤50EU/mg
氨基酸组成分析≤±10%
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/01/25 | HY-P0249A | 159237-99-7 Phe-Met-Arg-Phe amide trifluoroacetate | 159237-99-7 | 5mg | 950元 |
2024/01/25 | HY-P0249A | 159237-99-7 Phe-Met-Arg-Phe amide trifluoroacetate | 159237-99-7 | 10mg | 1550元 |