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Product Name:VU 6008667
CAS:2092923-21-0
Purity:99% Remarks:VU 6008667 is a selective negative allosteric modulator (NAM) of M5 muscarinic acetylcholine receptor (mAChR) (IC50 values of 1.2 and 1.6 μM in human and rat M5, respectively). Moreover, VU6008667 has
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VU 6008667 manufacturers
- VU 6008667
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- $854.00 / 25mg
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2025-12-09
- CAS:2092923-21-0
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | VU 6008667 Basic information |
| Product Name: | VU 6008667 | | Synonyms: | VU 6008667;5H-Imidazo[2,1-a]isoindol-5-one, 9b-(4-chloro-3-methylphenyl)-1-(3,4-difluorobenzoyl)-1,2,3,9b-tetrahydro-, (9bS)- | | CAS: | 2092923-21-0 | | MF: | C24H17ClF2N2O2 | | MW: | 438.85 | | EINECS: | | | Product Categories: | | | Mol File: | 2092923-21-0.mol |  |
| | VU 6008667 Chemical Properties |
| Boiling point | 616.1±55.0 °C(Predicted) | | density | 1.48±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 100 mg/mL (227.87 mM) | | pka | -2.76±0.40(Predicted) | | form | Solid | | color | Light yellow to yellow |
| | VU 6008667 Usage And Synthesis |
| Uses | VU 6008667 is a selective negative allosteric modulator of M5 NAM with IC50s of 1.2 μM and 1.6 μM for human M5 and rat M5, respectively. High CNS penetration[1]. | | in vivo | VU 6008667 (1 mg/kg)/PO (3 mg/kg, solution dose) displays a diminished elimination half-life (t1/2=2.3 hr) driven by a smaller volume (Vss=7.4 L/kg) and higher clearance (CLp=82 mL/min/kg), with moderate oral bioavailability (17% F)[1]. | Animal Model: | RAT (PK study)[1] | | Dosage: | 1 mg/kg; 3 mg/kg | | Administration: | oral adminstration | | Result: | Had a desired short half-life in rat (t1/2= 2.3 hr), with moderate oral bioavailability (17% F). |
| | IC 50 | mAChR5 | | References | [1] McGowan KM et al, Continued optimization of the M5 NAM ML375: Discovery of VU6008667, an M5 NAM with high CNS penetration and a desired short half-life in rat for addiction studies. Bioorg Med Chem Lett. 2017 Mar 15;27(6):1356-1359. DOI:10.1016/j.bmcl.2017.02.020 |
| | VU 6008667 Preparation Products And Raw materials |
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