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欧前胡素

欧前胡素 更多供应商
公司名称: 上海源叶生物科技有限公司  黄金产品
联系电话: 15800763013 021-61312847
产品介绍: 中文名称:欧前胡素
英文名称:Imperatorin
CAS:482-44-0
纯度:HPLC≥98% 包装信息:20mg 备注:生化试剂
公司名称: 成都川研医工生物科技有限公司  黄金产品
联系电话: 18280298385
产品介绍: 中文名称:欧前胡素
英文名称:Imperatorin
CAS:482-44-0
纯度:HPLC≥98% 包装信息:20MG;50MG;100MG;200MG;1G;10G;多规格定制
公司名称: 北京百灵威科技有限公司  
联系电话: 400-666-7788 010-82848833
产品介绍: 中文名称:欧前胡素
英文名称:Imperatorin, 98%
CAS:482-44-0
纯度:98% 包装信息:10MG;50MG 备注:化学试剂、精细化学品、医药中间体、材料中间体
公司名称: 上海佰世凯化学科技有限公司  
联系电话: 021-20908456
产品介绍: 英文名称:MARMELOSIN (IMPERATORIN)
CAS:482-44-0
备注:C11428
公司名称: 凯试(上海)科技有限公司  
联系电话: 021-50135380
产品介绍: 英文名称:IMperatorin
CAS:482-44-0
纯度:98% 备注:1620元/10mg; 10000元/100mg
欧前胡素专题
欧前胡素的相关研究
欧前胡素(imperatorin)和异欧前胡素(iso-impemtorin)属于6.7-峡喃香豆素类.广泛分布于植物界,尤其伞形科常用中药如白芷、独活、前胡、羌活、北沙参等含且丰富,而且是其主要药理效应成分。香豆素类化合物具有较高的应用价值和较多的生
2021/10/20 13:18:39
欧前胡素生产厂家及价格列表
欧前胡素_南京源植生物科技有限公司
价格:询价
2022/01/25 17:51:00
欧前胡素_武汉天植生物技术有限公司
价格:询价
2022/01/25 13:54:09
欧前胡素
简介植物来源药理作用生物活性靶点体外研究体内研究 MSDS 用途与合成方法 欧前胡素价格(试剂级) 上下游产品信息 专题
中文名称:欧前胡素
中文同义词:欧前胡素;白茅苷;前胡素;主人草素;殴前胡素;欧前胡素(欧芹属素乙;IMPERATORIN 欧前胡素 标准品;欧前胡素(分析标准品)
英文名称:Imperatorin
英文同义词:2-g)(1)benzopyran-7-one,9-((3-methyl-2-butenyl)oxy)-7h-furo(;6-hydroxy-7-((3-methyl-2-butenyl)oxy)-5-benzofuranacrylicacidelta-lacto;6-hydroxy-7-((3-methyl-2-butenyl)oxy)-5-benzofuranacrylicacidelta-lactone;6-hydroxy-7-(3-methyl-2-butenyloxy)-5-benzofuranacrylicacidomega-lactone;8-isopentenyloxypsoralene;9-((3-methyl-2-butenyl)oxy)-7h-furo(3,2-g)(1)benzopyran-7-one;9-[(3-methyl-2-butenyl)oxy]-7h-furo[3,2-g][1]benzopyran-7-one;IMPERATORIN
CAS号:482-44-0
分子式:C16H14O4
分子量:270.28
EINECS号:207-581-1
相关类别:中草药成分;分析对照品;标准品-对照品;中药对照品;标准品;对照品,标准品;分析标准品;植物提取物;chemical reagent;pharmaceutical intermediate;phytochemical;对照品;植提标准品;小分子抑制剂;Inhibitors;小分子抑制剂,天然产物;生物活性小分子;标准品-中药标准品;木脂素;标准品 -中药标准品;分析试剂-对照品;标准品,对照品;植物提取物单体;化妆品原料;Coumarins;Intermediates & Fine Chemicals;Pharmaceuticals;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
Mol文件:482-44-0.mol
欧前胡素
欧前胡素 性质
熔点 98-100°C
沸点 333.4°C (rough estimate)
密度 1.1311 (rough estimate)
折射率 1.4350 (estimate)
储存条件 -20°C
溶解度 DMSO: ≥5mg/mL
形态powder
颜色off-white to light brown
最大波长(λmax)301nm(MeOH)(lit.)
Merck 14,4925
InChIKeyOLOOJGVNMBJLLR-UHFFFAOYSA-N
CAS 数据库482-44-0(CAS DataBase Reference)
NIST化学物质信息7H-furo[3,2-g][1]benzopyran-7-one, 9-[(3-methyl-2-butenyl)oxy]-(482-44-0)
欧前胡素 用途与合成方法
简介

欧前胡素(imperatorin)和异欧前胡素(iso-impemtorin)属于6.7-峡喃香豆素类,广泛分布于植物界,尤其伞形科常用中药如白芷、独活、前胡、羌活、北沙参等含且丰富,而且是其主要药理效应成分。

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植物来源在自然界中的含有欧前胡素的植物主要有以下几种:
1.大风子科(Flacourtiaceae)
罗旦梅Flacourtia jangomas(Lour.) Raeusch茎,皮
2.芸香科(Rutaceae)
米申酒饼簕* Atalantia missionis Oliver 根,茎皮(收率:4.1%)
被小绒毛芸香* Eriostemon tomentellus 地上部分
三狭叶藤桔* Luvunga angustifolia茎(收率:0.0026%)
3.伞形科(Umbelliferae)
宽叶高伞* Agasyllis latifolia
密花岩风 Libanotis condensata (L.) Crantz
西吉藁本* Ligusticum seguieri Koch根
欧前胡 Peucedanum ostruthium L.根
克氏邪蒿* Seseli krylovii
短尖邪蒿 Seseli mucronatum根
药理作用抗疟作用:欧前胡素对恶性疟原虫的IC50为2.4μg/mL,IC90为9.3μg/mL。
抗菌作用:对革兰阳性菌有选择性活性。
生物活性Imperatorin 是一种有效的 NO synthesis 抑制剂,IC50 为 9.2 μmol,也是 BChE 抑制剂,IC50 为 31.4 μmol。Imperatorin 是 TRPV1 的微弱激动剂,EC50 为 12.6±3.2 μM。
靶点

IC50: 9.2 μmol (NO synthesis), 31.4 μmol (BChE)EC50: 12.6±3.2 μM (TRPV1)

体外研究

Imperatorin is a plant secondary metabolite belonging to the coumarins-specifically the furanocoumarins. Imperatorin enhances the GABA-induced chloride ion current (I GABA ) through the α 1 β 2 γ 2S receptors. Imperatorin potentiates I GABA at 100 μmol by 50.5±16.3 % and at 300 μmol by 109.8±37.7 %, respectively. Imperatorin, together with Phellopterin, found in the roots of A. dahurica, inhibit [ 3 H]diazepam binding to the benzodiazepine site of the rat brain GABA A receptor in vitro with an IC 50 of 12.3 μmol for Imperatorin and 400 nmol for Phellopterin. Imperatorin, in a concentration ranging from 3.5 to 14 mmol, significantly and irreversibly inhibits GABA-T in a time-dependent and concentration-dependent manner, by irreversibly binding with the active site of GABA-T.Imperatorin is a reversible acetylcholinesterase (AChE) inhibitor, and acts in dose-dependent manner. The AChE and BChE inhibitory activities of Imperatorin and a crude extract from the fruits of Angelica archangelica L. is tested by the spectrophotometric method at concentrations of 12.5, 25, 50, and 100 μg/mL. Imperatorin displays low inhibition towards AChE (13.75-46.11 %), whereas it has remarkable inhibitory effect against BChE (37.46-83.98 %). Imperatorin shows selectivity toward BChE rather than AChE, with an IC 50 for BChE of 31.4 μmol. Imperatorin, together with (+)-Byakangelicol, are found to be the most effective BACE-1 inhibitors, with IC 50 s of 91.8 and 104.9 μmol, respectively. Imperatorin (IC 50 =9.2 μmol) is also effective as an inhibitor of NO synthesis. Imperatorin is a weak agonist of TRPV1, a channel implicated in detecting several noxious stimuli, exhibiting EC 50 of 12.6±3.2 μM.

体内研究

At doses of 10 and 20 mg/kg and 30 min after injection, Imperatorin shows an anxiolytic effect and improved different stages of memory and learning processes-both acquisition and consolidation. It is also shown that acute administration Imperatorin at doses of 10 and 20 mg/kg reduced the anxiogenic effect of nicotine (0.1 mg/kg, subcutaneous, s.c.). At 30 and 40 mg/kg, i.p. Imperatorin significantly potentiates the anticonvulsant activity of carbamazepine against maximal electroshock-induced seizures expressed by lowering the ED 50 from 10.8 to 6.8 mg/kg (by 34 %) and 6 mg/kg (by 42 %), respectively. Moreover, Imperatorin at 30 mg/kg and carbamazepine at 6.8 mg/kg shows increases the total brain concentration of carbamazepine from 1.260 to 2.328 μg/mL (by 85%), which may be caused by modifying the blood-barrier permeability or acting like an inhibitor of multi-drug resistance proteins. Imperatorin, a naturally occurring furanocoumarin, inactivates gamma-aminobutyric acid transaminase and inhibits acetylcholinesterase activity. Imperatorin administered acutely at the doses of 5 and 10 mg/kg prior to the injection of scopolamine (1 mg/kg) improves memory acquisition and consolidation impaired by scopolamine. Furthermore, repeatable (7 days, twice daily) administration of the highest dose of Imperatorin (10 mg/kg) significantly attenuates the effects of scopolamine on memory acquisition, whereas the doses of 5 and 10 mg/kg of this furanocoumarin are effective when memory consolidation is measured .

化学性质 来源于大风子科(Flacourtiaceae) 罗旦梅 Flacourtiajangomas(Lour.)Raeusch茎,
用途 用于含量测定/鉴定/药理实验等。
药理药效:欧前胡素具有抗菌、平喘及抗过敏等作用。
用途 一种存在于柑橘类水果中的糠香豆素,用于HIV-1研究。Imperatorin is a furocoumarin present in citrus fruits, which is used in HIV-1 research. Studies indicate that the transcription factor Sp1 is essential in the inhibitory functions of Imperatorin. In addition, Imperatorin inhibits cyclin D1 expression and stops the cell cycle at G1. These studies also suggest that Imperatorin suppresses HIV-1 replication in primary T lymphocytes and transformed cell lines. Furthermore, it has been suggested that the inhibitory effects of Imperatorin on HIV-1 at the transcriptional level can be monitored effectively in HeLa cells. Imperatorin can also cause apoptosis in human promyelocytic leukaemia, HL-60 via the cytochrome c/caspase-9 pathway.
安全信息
安全说明 24/25
WGK Germany 3
RTECS号LV1575000
海关编码 29419090
毒害物质数据482-44-0(Hazardous Substances Data)
欧前胡素 价格(试剂级)
更新日期产品编号产品名称CAS编号包装价格
2022/01/17I0904欧前胡素
Imperatorin
482-44-025mg540元
2022/01/17I0904欧前胡素
Imperatorin
482-44-0100mg1530元
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