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11-Deoxy-11-methylene-15-keto prostaglandin d2

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Company Name: Shanghai Hongye Biotechnology Co. Ltd  
Tel: 400-9205774 400-920-5774
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11-Deoxy-11-methylene-15-keto prostaglandin d2 Basic information
Product Name:11-Deoxy-11-methylene-15-keto prostaglandin d2
Synonyms:9ALPHA,HYDROXY-11-METHYLENE-15-OXO-PROSTA-5Z,13E-DIEN-1-OIC ACID;SAAKCJFTIGHOEX-WQXLGBCHSA-N;Prosta-5,13-dien-1-oic acid, 9-hydroxy-11-methylene-15-oxo-, (5Z,9α,13E)-;11-Deoxy-11-methylene-15-keto prostaglandin d2
CAS:958759-75-6
MF:C21H32O4
MW:348.48
EINECS:
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Mol File:Mol File
11-Deoxy-11-methylene-15-keto prostaglandin d2 Structure
11-Deoxy-11-methylene-15-keto prostaglandin d2 Chemical Properties
solubility DMF: 100 mg/ml; DMSO: 100 mg/ml; Ethanol: 100 mg/ml; PBS (pH 7.2): 2 mg/ml
Safety Information
MSDS Information
11-Deoxy-11-methylene-15-keto prostaglandin d2 Usage And Synthesis
DescriptionProstaglandin D2 (PGD2) is one of the five primary enzymatic prostaglandins derived directly from PGH2. Many of the biological effects of PGD2 are transduced in vivo by a classical 7-transmembrane GPCR, the DP1 receptor.1 However, a second receptor, the chemokine-related CRTH2 receptor, also binds PGD2.2,3 This new receptor was recently identified on human eosinophils, where it binds selectively the PGD2 metabolite 13,14-dihydro-15-keto PGD2.4 11-deoxy-11-methylene-15-keto PGD2 was prepared as a more chemically stable ligand for this receptor. There are no published studies of the pharmacological properties of 11-deoxy-11-methylene-15-keto PGD2.
DefinitionChEBI: 11-Deoxy-11-methylene-15-keto-PGD2 is a prostanoid.
References1. Boie, Y., Sawyer, N., Slipetz, D.M., et al. Molecular cloning and characterization of the human prostanoid DP receptor J. Biol. Chem. 270(32),18910-18916(1995).
2. Gervais, F.G., Cruz, R., Chateauneuf, A., et al. Selective modulation of chemokinesis, degranulation, and apoptosis in eosinophils through the PGD2 receptors CRTH2 and DP J. Allergy Clin. Immunol. 108(6),982-988(2002).
3. Monneret, G., Gravel, S., Diamond, M., et al. Prostaglandin D2 is a potent chemoattractant for human eosinophils that acts via a novel DP receptor Blood 98(6),1942-1948(2001).
4. Hirai, H., Tanaka, K., Yoshie, O., et al. Prostaglandin D2 selectivity induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2 J. Exp. Med. 193(2),255-261(2001).
11-Deoxy-11-methylene-15-keto prostaglandin d2 Preparation Products And Raw materials
Tag:11-Deoxy-11-methylene-15-keto prostaglandin d2(958759-75-6) Related Product Information
11-Deoxy-11-methylene prostaglandin d2 9-Deoxy-9-methylene-16,16-dimethyl prostaglandin E2 9-Deoxy-9-methylene prostaglandin E2 13,14-Dihydro-15-keto prostaglandin d2 15-deoxy-Δ12,14-Prostaglandin D2-d9