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主な危険性 | F,Xi | Rフレーズ | 11-36/37/38 | Sフレーズ | 16-26-36 | RIDADR | UN 2347 3/PG 2 | WGK Germany | 3 | RTECS 番号 | TZ7630000 | F | 13 | 国連危険物分類 | 3.1 | 容器等級 | II | HSコード | 29309090 |
| イソブチルメルカプタン Usage And Synthesis |
外観 | 無色~うすい黄色、液体 | 化学的特性 | 2-Methyl-1-propanethiol has a cooked vegetable, almost mustard-like, odor | 化学的特性 | Liquid; unpleasant odor. | 天然物の起源 | Reported found in guava, milk, cooked beef, cooked pork and beer. | 使用 | Flammable, dangerous fire risk. | 一般的な説明 | 2-methyl-1-propanethiol attaches with L-Cys (the carrier) via a disulfide bond to form the brain-targeted drug delivery systems (BTDS). | 純化方法 | Dissolve the thiol in EtOH, and add to 0.25M Pb(OAc)2 in 50% aqueous EtOH. The precipitated lead mercaptide is filtered off, washed with a little EtOH, and impurities are removed from the molten salt by steam distillation. After cooling, dilute HCl is added dropwise to the residue, and the mercaptan is distilled directly from the flask. Water is separated from the distillate, and the mercaptan is dried (Na2CO3) and distilled under nitrogen. [Mathias J Am Chem Soc 72 1897 1950, Beilstein 1 H 378, 1 I 191, 1 II 412, 1 III 1565, 1 IV 1605.] |
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