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| | 4-AMINO-2,3-DIFLUORO-PHENOL Basic information |
| Product Name: | 4-AMINO-2,3-DIFLUORO-PHENOL | | Synonyms: | 4-AMINO-2,3-DIFLUORO-PHENOL;2,3-DIFLUORO-4-HYDROXYANILINE;Phenol, 4-amino-2,3-difluoro- (9CI);Phenol, 4-amino-2,3-difluoro-;4-Amino-2,3-difluorophenol,98%;4-AMINO-2,3-DIFLUORO-PHENOL ISO 9001：2015 REACH | | CAS: | 163733-99-1 | | MF: | C6H5F2NO | | MW: | 145.11 | | EINECS: | | | Product Categories: | HALIDE;Aromatic Phenols;pharmacetical;Phenol&Thiophenol&Mercaptan | | Mol File: | 163733-99-1.mol |  |
| | 4-AMINO-2,3-DIFLUORO-PHENOL Chemical Properties |
| Melting point | ca 153℃ | | Boiling point | 255.5±40.0 °C(Predicted) | | density | 1.472±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | | form | powder | | pka | 7.99±0.23(Predicted) | | color | Black |
| Hazard Codes | Xi | | RIDADR | UN2928 | | Hazard Note | Irritant | | HazardClass | 6.1, 8 | | HS Code | 2908990000 |
| | 4-AMINO-2,3-DIFLUORO-PHENOL Usage And Synthesis |
| Chemical Properties | brown toblack powde | | Uses | 4-Amino-2,3-difluorophenol is one of the 4-aminophenol metabolites used to study dehalogenation. | | Synthesis | Under hydrogen atmosphere (30 psi), 1-benzyloxy-2,3-difluoro-4-nitrobenzene (14 g, 52.8 mmol) was dissolved in methanol (200 mL), 10% Pd/C catalyst (1.4 g, 1.3 mmol) was added, and the reaction was stirred for 2 hours. After completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated in vacuum to afford 4-amino-2,3-difluorophenol (7 g, 92% yield). The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 9.05 (s, 1H), 6.45 (t, J = 8.8 Hz, 1H), 6.34 (t, J = 9.2 Hz, 1H), 4.67 (s, 2H); Mass Spectra (ESI) m/z: 146.1 [M + H]+. | | References | [1] Patent: US2008/90856, 2008, A1. Location in patent: Page/Page column 41
[2] Patent: WO2010/51373, 2010, A1. Location in patent: Page/Page column 61
[3] Patent: WO2013/36232, 2013, A2. Location in patent: Paragraph 00279
[4] Patent: WO2013/180949, 2013, A1. Location in patent: Paragraph 0180
[5] Patent: WO2014/22116, 2014, A2. Location in patent: Paragraph 0177 |
| | 4-AMINO-2,3-DIFLUORO-PHENOL Preparation Products And Raw materials |
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