9,10-二羟基十八酸
中文名称 | 9,10-二羟基十八酸 |
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中文同义词 | 9,10-二羟基十八酸;9,10-二羟基硬脂酸;9,10-双羟基十八烷酸;9,10-二羥十八酸;9,10-二羥硬脂酸;二羟基硬脂酸;9,10-二羟硬脂酸;9,10-二羟基十八烷酸 |
英文名称 | 9,10-DIHYDROXYSTEARIC ACID |
英文同义词 | AKOS 236-72;9 10-DIHYDROXYOCTADECANOIC ACID;9,10-DIHYDROXYSTEARIC ACID;20731-55-9 (Hydrochloride salt);37734-46-6 (Potassium salt);60154-91-8 (Lithium salt);74220-13-6 (Di-calcium salt);84682-00-8 (Magnesium salt) |
CAS号 | 120-87-6 |
分子式 | C18H36O4 |
分子量 | 316.48 |
EINECS号 | 204-432-2 |
相关类别 | |
Mol文件 | 120-87-6.mol |
结构式 |
9,10-二羟基十八酸 性质
熔点 | 90°C |
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沸点 | 375.89°C (rough estimate) |
密度 | 0.9730 (rough estimate) |
折射率 | 1.4434 (estimate) |
溶解度 | DMF:25mg/mL;二甲基亚砜:10mg/mL; DMSO:PBS (pH 7.2) (1:5):0.16mg/mL;乙醇:5mg/mL |
形态 | 结晶固体 |
酸度系数(pKa) | 4.78±0.10(Predicted) |
9,10-Dihydroxystearic acid 是油酸的氧化产物,可以改善 KKAy 小鼠的葡萄糖耐量和胰岛素敏感性。
5-20 μmol/L 9,10-Dihydroxystearic acid (DHSA) does not activate PPAR-γ in CV-1 cells but 50-100 μmol/L DHSA activates PPAR-γ in a dose-dependent way. 9,10-Dihydroxystearic acid does not activate PPAR-α in CV-1 cells.
9,10-Dihydroxystearic acid (DHSA; fed with high fat diet containing 4% DHSA; for 5-6 weeks) treatment improves glucose tolerance and insulin sensitivity in KKAy mice.