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| | 4-Bromo-2,6-difluorophenol Basic information |
| Product Name: | 4-Bromo-2,6-difluorophenol | | Synonyms: | 4-BROMO-2,6-DIFLUOROPHENOL;2,6-Difluoro-4-Bromophenol 4-Bromo-2,6-Difluoro Phenol;2,6-Difluoro-4-bromophenol;4-Bromo-2,6-difluorophenol 98%;4-Bromo-2,6-difluorophenol98%;Phenol,4-bromo-2,6-difluoro-;4-Bromo-2,6-difL;4-BROMO-2,6-DIFLUOROPHENOL ISO 9001：2015 REACH | | CAS: | 104197-13-9 | | MF: | C6H3BrF2O | | MW: | 208.99 | | EINECS: | 642-788-4 | | Product Categories: | Aromatic Phenols;Phenol&Thiophenol&Mercaptan | | Mol File: | 104197-13-9.mol |  |
| | 4-Bromo-2,6-difluorophenol Chemical Properties |
| Melting point | 50°C | | Boiling point | 180.2±35.0 °C(Predicted) | | density | 1.858±0.06 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Room Temperature | | pka | 6.89±0.23(Predicted) | | Appearance | Off-white to light yellow Solid | | BRN | 8543473 | | InChI | InChI=1S/C6H3BrF2O/c7-3-1-4(8)6(10)5(9)2-3/h1-2,10H | | InChIKey | GPRPSJPFAAGLCA-UHFFFAOYSA-N | | SMILES | C1(O)=C(F)C=C(Br)C=C1F | | CAS DataBase Reference | 104197-13-9(CAS DataBase Reference) |
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ALFA
| English |
| | 4-Bromo-2,6-difluorophenol Usage And Synthesis |
| Chemical Properties | White crystalline | | Uses | 4-Bromo-2,6-difluorophenol is used as an intermediate in pharmaceuticals and liquid crystal materials. | | Synthesis |
To a solution of 2,6-Difluorophenol (10.0 g, 76.86 mmol) in DMF (60 mL), N-bromosuccinimide (13.68 g, 76.86 mmol) was added at 0° C. and stirred at RT for 20 h. The reaction mixture was concentrated, diluted with water and extracted with ethyl acetate. The organic layer was dried over sodium sulphate and concentrated under reduced pressure to afford 4-Bromo-2,6-difluorophenol as a light yellow liquid (15.1 g, 93 percent yield). 1H-NMR (δ ppm, DMSO-D6, 400 MHz): δ 10.49 (s, 1H), 7.35 (d, J=6.2 Hz, 2H).
| | References | [1] Patent: US2011/118257, 2011, A1. Location in patent: Page/Page column 100
[2] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 3, p. 608 - 617
[3] Patent: WO2014/209034, 2014, A1. Location in patent: Paragraph 410; 411; 412
[4] Journal of Medicinal Chemistry, 2016, vol. 59, # 7, p. 3183 - 3203
[5] Patent: EP3239143, 2017, A2. Location in patent: Paragraph 0101 |
| | 4-Bromo-2,6-difluorophenol Preparation Products And Raw materials |
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