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吉非罗齐杂质A

吉非罗齐杂质A 更多供应商
公司名称: 北京百灵威科技有限公司  
联系电话: 400-666-7788 010-82848833
产品介绍: 英文名称:Chlorguanide Hydrochloride
CAS:637-32-1
包装信息:10Mg,250Mg,50Mg 备注:化学试剂、精细化学品、医药中间体、材料中间体
公司名称: 凯试(上海)科技有限公司  
联系电话: 021-50135380
产品介绍: 英文名称:Chlorguanide Hydrochloride
CAS:637-32-1
纯度:98% 备注:1500元/10mg; 2454元/50mg; 8750元/250mg
公司名称: BOC Sciences  
联系电话: 16314854226
产品介绍: 英文名称:Proguanil hydrochloride
CAS:637-32-1
备注:Proguanil hydrochloride is the hydrochloride salt form of proguanil, which is a synthetic biguanide derivative of pyrimidine. It is used as an folate antagonist with antimalarial property. It is used
公司名称: 上海陶术生物科技有限公司  
联系电话: 15002134094 021-33632979
产品介绍: 中文名称:盐酸氯胍
英文名称:Proguanil hydrochloride
CAS:637-32-1
纯度:90%-99% 包装信息:5 mg;25 mg;50 mg;100 mg;200 mg;10 mg; 备注:试剂级,仅用于科研使用
公司名称: 上海陶素生化科技有限公司  
联系电话: 021-33632979
产品介绍: 英文名称:CHLOROGUANIDE HYDROCHLORIDE
CAS:637-32-1
纯度:90% 包装信息:1Mg 备注:仅供科研使用
最新发布供应信息
吉非罗齐杂质A_陕西缔都医药化工有限公司
2021/9/27 8:08:50
吉非罗齐杂质A
生物活性体外研究体内研究
中文名称:吉非罗齐杂质A
中文同义词:盐酸氯胍;N1-(4-氯苯基)-N5-异丙基双胍盐酸盐;盐酸氯胍 标准品;盐酸氯胍 USP标准品;吉非罗齐杂质A;盐酸丙胍
英文名称:Chlorguanide Hydrochloride
英文同义词:1-(p-chlorophenyl)-5-isopropylbiguanidehydrochloride;N1-(4-Chlorophenyl)-N5-isopropylbiguanide Hydrochloride;1-(p-chlorophenyl)-5-isopropyl-biguanidmonohydrochloride;3359rp;chlorguanidehydrochloride;chloroguanidehydrochloride;chloroguanidinehydrochloride;diguanyl
CAS号:637-32-1
分子式:C11H17Cl2N5
分子量:290.19
EINECS号:211-283-7
相关类别:Aromatics;Bases & Related Reagents;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals;PALUDRINE
Mol文件:637-32-1.mol
吉非罗齐杂质A
吉非罗齐杂质A 性质
熔点 249-2510C
储存条件 2-8°C
溶解度 acetonitrile: water: ~1mg/mL (60/40)
形态solid
吉非罗齐杂质A 用途与合成方法
生物活性Proguanil hydrochloride是一种抗疟前药,被代谢为活性代谢物环鸟苷 (HY-12784)。Proguanil hydrochloride是一种二氢叶酸还原酶 (DHFR) 抑制剂。
体外研究

Proguanil per se has only weak antimalarial activity in vitro (IC 50 =2.4-19 μM), and its effectiveness depends on the active metabolite Cycloguanil (IC 50 =0.5-2.5 nM). The Cycloguanil is a dihydrofolate reductase (DHFR) inhibitor. The combination of Atovaquone and Proguanil is synergistic in vitro . Both drugs also have activity against gametocytes and pre-erythrocytic (hepatic) stages of malaria parasites.
Proguanil acts as a biguanide rather than as its metabolite Cycloguanil (a parasite dihydrofolate reductase [DHFR] inhibitor) to enhance the Atovaquone effect. Proguanil-mediated enhancement is specific for Atovaquone, since the effects of other mitochondrial electron transport inhibitors, such as Myxothiazole and Antimycin, are not altered by inclusion of Proguanil.
5-HT 3 receptor responses are reversibly inhibited by Proguanil, the metabolite 4-chlorophenyl-1-biguanide (CPB) and the active metabolite Cycloguanil (CG), with an IC 50 of 1.81, 1.48 and 4.36 μM, respectively.

体内研究

Proguanil (p.o.; 2.9 mg/kg body weight; daily for 5 days and 6 weeks respectively) shows mild degenerative changes for five days, while shows severe degenerative changes for six weeks in wistar strain albino rats.
Serum testosterone level is significantly decreased for proguanil treatment rats.
Administration of Malarone (Atovaquone and Proguanil) to experimentally B. gibsoni infected two dogs in chronic stage and three dogs in acute stage results in decrease in parasitemia, and clinical improvements are observed.

安全信息
危险品标志 T
危险类别码 25
安全说明 45
危险品运输编号 3249
WGK Germany 3
RTECS号DU1750000
HazardClass 6.1(b)
PackingGroup III
海关编码 2925294500
毒性LD50 orally in rats: 200 mg/kg (Schmidt)
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