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| | Chlorguanide Hydrochloride Basic information |
| | Chlorguanide Hydrochloride Chemical Properties |
| Melting point | 249-2510C | | storage temp. | 2-8°C | | solubility | acetonitrile: water: ~1mg/mL (60/40) | | form | solid |
| Hazard Codes | T | | Risk Statements | 25 | | Safety Statements | 45 | | RIDADR | 3249 | | WGK Germany | 3 | | RTECS | DU1750000 | | HazardClass | 6.1(b) | | PackingGroup | III | | HS Code | 2925294500 | | Toxicity | LD50 orally in rats: 200 mg/kg (Schmidt) |
| | Chlorguanide Hydrochloride Usage And Synthesis |
| Chemical Properties | White Solid | | Uses | Proguanil (chlorguanide) may be used in anti-parasitic protozoan drug development to study its pharmacokinetics, metabolism, safety, efficacy and methods of delivery as an antimalarial drug. | | Uses | Chlorguanide Hydrochloride can be intended for use as an internal standard for the quantification of Proguanil by GC- or LC-mass spectrometry. | | Brand name | Paludrine (Zeneca). | | General Description | Proguanil hydrochloride is a biguanide compound, widely used as an antimalarial drug. It exhibits sporontocidal activity, thereby rendering the gametocytes non-infective to the mosquito vector.
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. | | Biochem/physiol Actions | Chlorguanide (proguanil) is combined with atovaquone for malaria prophylaxis. The two compounds act synergistically to inhibit the plasmodial dihydrofolate reductase (DHFR) and interrupt the electron transport chain. Mutations in DHFR account for the development of resistant strains. |
| | Chlorguanide Hydrochloride Preparation Products And Raw materials |
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