| Company Name: |
J & K SCIENTIFIC LTD.
|
| Tel: |
010-82848833 400-666-7788 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:DenatoniuM Benzoate Hydrate
CAS:86398-53-0
Package:100Mg,25Mg
|
| Company Name: |
Sinopharm Chemical Reagent Co,Ltd.
|
| Tel: |
86-21-63210123 |
| Email: |
sj_scrc@sinopharm.com |
| Products Intro: |
Product Name:Denatonium Benzoate (200 mg)
CAS:86398-53-0
Package:200 mg
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Email: |
marketing@energy-chemical.com |
| Products Intro: |
Product Name:Denatonium Benzoate Hydrate
CAS:86398-53-0
Purity:NULL Package:100mg;25mg Remarks:NULL
|
|
| | Denatonium Benzoate Monohydrate Basic information |
| Product Name: | Denatonium Benzoate Monohydrate | | Synonyms: | DENATONIUM BENZOATE (200 MG)I1F0251.000MG/MG(DR);Benzenemethanaminium, N-(2-((2,6-dimethylphenyl)amino)-2-oxoethyl)-N,N-diethyl-, benzoate, monohydrate;Denatonium benzoate [usan:inn:ban];Denatonium Benzoate (200 mg);DenatoniuM Benzoate Hydrate | | CAS: | 86398-53-0 | | MF: | C28H36N2O4 | | MW: | 464.59644 | | EINECS: | | | Product Categories: | | | Mol File: | 86398-53-0.mol |  |
| | Denatonium Benzoate Monohydrate Chemical Properties |
| solubility | Very soluble in chloroform, and methanol; soluble in ethanol (95%), and water; sparingly soluble in acetone; practically insoluble in ether. |
| | Denatonium Benzoate Monohydrate Usage And Synthesis |
| Chemical Properties | Denatonium benzoate occurs as an odorless, very bitter tasting, white crystalline powder or granules. | | Uses | Pharmaceutic aid (alcohol denaturant); pharmaceutic aid (flavor). | | Uses | Denatonium Benzoate Hydrate is a stimulant of the bitter taste receptors which allows for maintenance of the airways. Bronchodilator. | | Production Methods | Denatonium benzoate was first synthesized in the 1950s and is usually prepared by reacting denatonium chloride with benzyl benzoate. | | Brand name | Bitrex (Mac Farlan Smith, Scotland). | | Pharmaceutical Applications | Denatonium benzoate is among the most bitter of substances
known and is detectable at concentrations of approximately 10 ppb.
In pharmaceutical and other industrial applications it is added to
some products as a deterrent to accidental ingestion. It is most
commonly used at levels of 5–500 ppm. Denatonium benzoate may
also be used to replace brucine or quassin as a denaturant for
ethanol.
In pharmaceutical formulations, denatonium benzoate has been
used as a flavoring agent in placebo tablets, and in a topical
formulation it has been used in an anti-nailbiting preparation. | | Safety | Denatonium benzoate is generally regarded as a nonirritant and nonmutagenic substance.However,there has been a single report of contact urticaria attributed to denatonium benzoate occurring in a 30-year-old man who developed asthma and pruritus after using an insecticidal spray denatured with denatonium benzoate.
LD50 (rabbit, oral): 0.508g/kg
LD50 (rat, oral): 0.584g/kg | | storage | Denatonium benzoate is stable up to 140°C and over a wide pH range. It should be stored in a well-closed container (such as polythene-lined steel) in a cool, dry place. Aqueous or alcoholic solutions retaintheir bitterness forseveral years evenwhenexposed to light. | | Incompatibilities | Denatonium benzoateis incompatible with strongoxidizing agents. | | Regulatory Status | Denatonium benzoate is used worldwide as a denaturant for alcohol. It is included in the FDA Inactive Ingredients Database (topical gel and solution). |
| | Denatonium Benzoate Monohydrate Preparation Products And Raw materials |
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