9-氨基-1,2,3,4-四氢吖啶 盐酸盐 水合物
中文名称 | 9-氨基-1,2,3,4-四氢吖啶 盐酸盐 水合物 |
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中文同义词 | THA 盐酸盐 水合物;单满吖啶氨 盐酸盐 水合物;他克林盐酸盐;他克林盐酸盐水合物;盐酸他克林水合物;他克林盐酸盐一水合物;4-四氢吖啶 盐酸盐 水合物 |
英文名称 | 9-AMINO-1,2,3,4-TETRAHYDROACRIDINE HYDROCHLORIDE HYDRATE,99+% |
英文同义词 | 9-AMINO-1,2,3,4-TETRAHYDROACRIDINE HYDROCHLORIDE HYDRATE,99+%;Tacrine HCl hydrate;Cholinesterase (ChE),inhibit,Tacrine hydrochloride (hydrate),Inhibitor |
CAS号 | 206658-92-6 |
分子式 | C13H17ClN2O |
分子量 | 252.74 |
EINECS号 | |
相关类别 | 小分子抑制剂;小分子抑制剂,天然产物;抑制剂;Inhibitors |
Mol文件 | Mol File |
结构式 |
9-氨基-1,2,3,4-四氢吖啶 盐酸盐 水合物 性质
熔点 | 284-286°C (lit.) |
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储存条件 | Store at -20°C |
溶解度 | 在水中可溶 |
形态 | 粉末 |
颜色 | 淡黄色 |
Target | Value |
HNMT
() | |
cholinesterase
() |
Tacrine hydrochloride hydrate (12.5 to 37.5 nM) inhibits venom acetylcholinesterase as well as human serum butyrylcholinesterase in a concentration-dependent manner. The IC 50 is 31 nM for snake venom AChE and 25.6 nM for human BChE.
Pretreatment with Tacrine hydrochloride hydrate also modifies absolute levels of cocaine self-administration during reacquisition. Body weight declines approximately one-half percent over four days of treatment with intravenous Tacrine hydrochloride hydrate. Delivery of Tacrine hydrochloride hydrate by osmotic pump does not alter either linear- or repeated- cocaine-induced locomotor activity. There is no significant main effect or interaction with Tacrine hydrochloride hydrate treatment on active lever responding during reinstatement. Post hoc comparisons indicate that rats self-administering cocaine has significantly lower alkaline phosphatase levels, relative to Tacrine hydrochloride hydrate- but not saline- treated rats evaluated by conditioned-place preference.
安全信息
危险品标志 | T |
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危险类别码 | 23/24/25-36/37/38-40 |
安全说明 | 22-24/25-26-36/37/39 |
危险品运输编号 | UN 2811 6.1 / PGIII |
WGK Germany | 3 |
海关编码 | 2933998090 |
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/01/16 | S3639 | 9-氨基-1,2,3,4-四氢吖啶 盐酸盐 水合物 Tacrine hydrochloride hydrate | 206658-92-6 | 25mg | 1040.61元 |
2024/01/16 | S3639 | Tacrine hydrochloride hydrate | 206658-92-6 | 1g | 7944.3元 |