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| | SULFURETIN Basic information |
| Product Name: | SULFURETIN | | Synonyms: | SULFURETIN;6,3',4'-TRIHYDROXYAURONE;3',4',6-TRIHYDROXYAURONE;2-(3,4-dihydroxybenzylidene)-6-hydroxy-2H-benzofuran-3-one;(Z)-2-[(3,4-dihydroxyphenyl)methylene]-6-hydroxy-2H-benzofuran-3-one;SULPHURETIN;SULFURETIN WITH HPLC;SULFURETIN hplc | | CAS: | 120-05-8 | | MF: | C15H10O5 | | MW: | 270.24 | | EINECS: | 204-366-4 | | Product Categories: | Aurones | | Mol File: | 120-05-8.mol |  |
| | SULFURETIN Chemical Properties |
| Melting point | 295°C | | storage temp. | 2-8°C | | solubility | Acetone: Soluble
Chloroform: Soluble
Dichloromethane: Soluble
DMSO: SolubleEthyl Acetate: Soluble | | form | Solid | | color | Yellow to orange | | InChI | 1S/C15H10O5/c16-9-2-3-10-13(7-9)20-14(15(10)19)6-8-1-4-11(17)12(18)5-8/h1-7,16-18H/b14-6- | | InChIKey | RGNXWPVNPFAADO-NSIKDUERSA-N | | SMILES | OC1=CC=C2C(O/C(C2=O)=C\C3=CC(O)=C(O)C=C3)=C1 | | LogP | 1.980 (est) |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | SULFURETIN Usage And Synthesis |
| Uses | Sulfuretin inhibits the inflammatory response by suppressing the NF-κB pathway. Sulfuretin can be used for the research of allergic airway inflammation. Sulfuretin reduces oxidative stress, platelet aggregation, and mutagenesis[1]. Sulfuretin is a competitive and potent inhibitor of monophenolase and diphenolase activities with the IC50 of 13.64 μM[2]. | | Definition | ChEBI: Sulfuretin is a member of 1-benzofurans. | | Biological Activity | Anti-adipogenic, antineoplastic activity, antioxidative stress, Anti-Inflammatory | | in vivo | Sulfuretin inhibits the inflammatory responses by suppressing the NF-κB pathway in type 1 diabetes models. Sulfuretin (40 μg/kg; single intraperitoneal injection 2 h after the last OVA challenge) suppresses ovalbumin (OVA)-induced chemotaxis and airway inflammation[1]. | Animal Model: | Pathogen-free male BALB/c mice (7-8 weeks old)[1] | | Dosage: | 40 μg/kg | | Administration: | A single intraperitoneal injection was administered 2 h after the last OVA challenge | | Result: | Suppressed OVA-induced chemotaxis and airway inflammation.
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| | References | [1] Mi-Young Song, et al. Sulfuretin attenuates allergic airway inflammation in mice. Biochem Biophys Res Commun. 2010 Sep 10;400(1):83-8. DOI:10.1016/j.bbrc.2010.08.014
[2] Chen, H., et al. Isolation of sulfuretin and butin from Rhus verniciflua Stokes using medium-pressure liquid chromatography and their tyrosinase inhibitory effects. BioRes. 11(1), 759-771.
[3] SO YOUNG KANG Myung J O Ji Young Kang. Antiviral activities of flavonoids isolated from the bark of Rhus verniciflua stokes against fish pathogenic viruses In Vitro.[J]. Journal of Microbiology, 2012, 50 2: 293-300. DOI: 10.1007/s12275-012-2068-7 |
| | SULFURETIN Preparation Products And Raw materials |
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