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| | DB1113 Chemical Properties |
| density | 1.333±0.06 g/cm3(Predicted) | | pka | 12.82±0.70(Predicted) | | form | Solid | | color | White to off-white |
| | DB1113 Usage And Synthesis |
| Uses | DB1113 (Example 24) is a bifunctional compound targeted protein degradation of kinases. DB1113 degrades ABL1, ABL2, BLK, CDK11B, CDK4, CSK, EPHA3, FER, GAK, LIMK1, MAP3K20, MAP4K1, MAP4K2, MAP4K3, MAP4K5, MAPK14, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, NLK, PDIK1L, PTK2B, RIPK1, RPS6KA1, RPS6KA3, SIK2, SIK3, STK35, TNK2, and ULK1. DB1113 can be used for research of disease or disorder mediated by aberrant kinase activity[1]. | | IC 50 | CDK4; CDK11B; MAP4K2; SIK2; SIK3; MAP4K5; HPK1; GLK/MAP4K3; ULK1; LIMK1 | | References | [1] Gray Nathanael S, et al. Bifunctional compounds for targeted protein degradation of kinases: World Intellectual Property Organization, WO2022093742[P]. 2022-05-05. |
| | DB1113 Preparation Products And Raw materials |
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