CV-159
| 中文名称 | CV-159 |
|---|---|
| 中文同义词 | 化合物 T15021;化合物 CV-159 |
| 英文名称 | CV 159 |
| 英文同义词 | CV 159;1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl 5-[6-[(5-phenyl-1H-pyrazol-3-yl)oxy]hexyl] ester;3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-methyl 5-[6-[(5-phenyl-1H-pyrazol-3-yl)oxy]hexyl] ester;CV 159,CV159;1,4-Dihydro-2,6-dimethyl-4-(3--nitrophenyl)-3,5-pyridinedicarboxylic acid methyl-6-(5-phenyl-3-pyrazolyloxy)hexyl ester |
| CAS号 | 86384-98-7 |
| 分子式 | C31H34N4O7 |
| 分子量 | 574.63 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 86384-98-7.mol |
| 结构式 |  |
CV-159 性质
| 沸点 | 755.532±60.00 °C(Press: 760.00 Torr)(predicted) |
|---|---|
| 密度 | 1.249±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 11.787±0.10(predicted) |
CV-159 (0.1-10 μM) significantly inhibits TNF-α (10 ng/ml, 24 h)-induced VCAM-1 in SMCs in a concentrationdependent manner. CV-159 (10 μM, 30 min) significantly inhibits the TNF-induced ROS production. CV-159 (10 μM) inhibits TNF (24 h)-induced expression of e-selectin but not vascular cell adhesion molecule-1 and intercellular adhesion molecule-1. CV-159 inhibits TNF (20 min)-induced phosphorylation of JNK, p38, and NF-κB p65 (Ser536).
CV-159 (5 and 10 mg/kg, p.o.) gives significant protection against delayed neuronal death in the hippocampal CA1 region of the rats after 15-min transient forebrain ischemia. CV-159 also diminishes the size of the brain infarct after permanent middle cerebral artery (MCA) occlusion. CV-159 significantly reduces the increase in the water content of the infarcted cortex induced by MCA occlusion.