| Company Name: |
BOC Sciences |
| Tel: |
16314854226; +8616314854226 |
| Email: |
inquiry@bocsci.com |
CV 159 manufacturers
- CV-159
-
- $2500.00
-
2026-04-20
- CAS:86384-98-7
- Purity:
- Supply Ability: 10g
|
| Product Name: | CV 159 | | Synonyms: | CV 159;1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl 5-[6-[(5-phenyl-1H-pyrazol-3-yl)oxy]hexyl] ester;3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-methyl 5-[6-[(5-phenyl-1H-pyrazol-3-yl)oxy]hexyl] ester;CV 159,CV159;1,4-Dihydro-2,6-dimethyl-4-(3--nitrophenyl)-3,5-pyridinedicarboxylic acid methyl-6-(5-phenyl-3-pyrazolyloxy)hexyl ester | | CAS: | 86384-98-7 | | MF: | C31H34N4O7 | | MW: | 574.63 | | EINECS: | | | Product Categories: | | | Mol File: | 86384-98-7.mol |  |
| | CV 159 Chemical Properties |
| Boiling point | 755.532±60.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.249±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 11.787±0.10(predicted) |
| | CV 159 Usage And Synthesis |
| Uses | CV-159 is a unique dihydropyridine Ca2+ antagonist with an anti-calmodulin (CaM) action, and has antiinflammatory activities. | | in vivo | CV-159 (5 and 10 mg/kg, p.o.) gives significant protection against delayed neuronal death in the hippocampal CA1 region of the rats after 15-min transient forebrain ischemia. CV-159 also diminishes the size of the brain infarct after permanent middle cerebral artery (MCA) occlusion. CV-159 significantly reduces the increase in the water content of the infarcted cortex induced by MCA occlusion[3]. | | References | [1] Usui T, et al. Mechanisms underlying the anti-inflammatory effects of the Ca2+/calmodulin antagonist CV-159 in cultured vascular smooth muscle cells. J Pharmacol Sci. 2010;113(3):214-23. Epub 2010 Jun 16. DOI:10.1254/jphs.10100fp
[2] Usui T, et al. CV-159, a unique dihydropyridine derivative, prevents TNF-induced inflammatory responses in human umbilical vein endothelial cells. J Pharmacol Sci. 2010;113(2):182-91. Epub 2010 May 19. DOI:10.1254/jphs.10033fp
[3] Miyazaki H, et al. Neuroprotective effects of a dihydropyridine derivative, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarbox ylic acid methyl 6-(5-phenyl-3-pyrazolyloxy)hexyl ester (CV-159), on rat ischemic brain injury. Life Sci. 1999;64(10):869-78. DOI:10.1016/s0024-3205(99)00011-9 |
| | CV 159 Preparation Products And Raw materials |
|