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| | 6-chlorophenanthridine Basic information |
| Product Name: | 6-chlorophenanthridine | | Synonyms: | 6-chlorophenanthridine;MFCD01628084;6-Chlorophenanthridine 95+%;Phenanthridine,6-chloro-;6-chlorophenidine;6-Chloropyridine | | CAS: | 15679-03-5 | | MF: | C13H8ClN | | MW: | 213.66 | | EINECS: | | | Product Categories: | | | Mol File: | 15679-03-5.mol |  |
| | 6-chlorophenanthridine Chemical Properties |
| Melting point | 117-118 °C | | Boiling point | 377.7±15.0 °C(Predicted) | | density | 1.312±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | form | solid | | pka | 2.36±0.40(Predicted) | | color | Light beige | | InChI | InChI=1S/C13H8ClN/c14-13-11-7-2-1-5-9(11)10-6-3-4-8-12(10)15-13/h1-8H | | InChIKey | XHZTZKAXCPJABO-UHFFFAOYSA-N | | SMILES | C1C2C(=NC(Cl)=C3C=2C=CC=C3)C=CC=1 |
| | 6-chlorophenanthridine Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 6-chlorophenanthridine from 6(5H)-phenanthridone: Phosphoryl chloride (15 mL) and dimethylaniline (0.63 mL) were sequentially added to a reaction flask containing phenanthridine (2.0 g), followed by heating and refluxing for 3 hours. Upon completion of the reaction, the reaction solution was slowly poured into water and the solid product was precipitated. The solid was extracted with chloroform and the combined organic phases were dried over anhydrous sodium sulfate. The desiccant was removed by filtration and the filtrate was concentrated to dryness under reduced pressure. The resulting crude product was purified by column chromatography (eluent: chloroform) to afford the target compound 6-chlorophenanthridine (2.1 g, yield: 96%).1H NMR (300 MHz, CDCl3, TMS, room temperature): δ 8.63-8.60 (1H, d), 8.55-8.52 (1H, d), 8.50-8.48 (1H, d), 8.11-8.09 (1H, d). 8.09 (1H, d), 7.94-7.92 (1H, t), 7.79-7.66 (3H, m). | | References | [1] Patent: US2011/201802, 2011, A1. Location in patent: Page/Page column 10
[2] Patent: US9281483, 2016, B2. Location in patent: Page/Page column 83
[3] Patent: KR2016/30582, 2016, A. Location in patent: Paragraph 0162; 0163; 0164; 0165; 0166
[4] Dalton Transactions, 2014, vol. 43, # 44, p. 16872 - 16879
[5] Patent: CN105949246, 2016, A. Location in patent: Paragraph 0025; 0044-0046; 0049 |
| | 6-chlorophenanthridine Preparation Products And Raw materials |
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